Stem cells living with a Notch
Open accessAbstract
Notch signaling has been shown over the past few decades to play fundamental roles in a plethora of developmental processes in an evolutionarily conserved fashion. Notch-mediated cell-to-cell signaling is involved in many aspects of embryonic development and control of tissue homeostasis in a variety of adult tissues, and regulates stem cell maintenance, cell differentiation and cellular homeostasis. The focus of this Review is the role of Notch signaling in stem cells, comparing insights from flies, fish and mice to highlight similarities, as well as differences, between species, tissues and stem cell compartments.
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The increase in secretory lineage cells in aged intestinal stem cells implies deregulation of stem cell differentiation pathways in aged ISCs, most likely as a response to deregulated Notch signaling (e.g., elevated Atoh1).
“The increase in the number of secretory lineage cells, namely Paneth and goblet cells, also implies deregulation of stem cell differentiation pathways in aged ISCs, most likely as a response to deregulated Notch signaling, like elevated levels of Atoh1 expression (Kim et al., 2014; Koch et al., 2013; Tian et al., 2015).”
From Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells (2017) · cites this paper as Koch et al., 2013
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References 155 · Cited by 283
- Authors
- Koch, U., Lehal, R., & Radtke, F.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Corresponding author
- Radtke, Freddy
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2013-02-15
- Volume
- 140
- Issue
- 4
- Pages
- 689-704
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2127197885
- Cited by
- 283
- References
- 155
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 11 · 2023: 10 · 2022: 18 · 2021: 13 · 2020: 22 · 2019: 26 · 2018: 30 · 2017: 31 · 2016: 24 · 2015: 30 · 2014: 35 · 2013: 9
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- Notch signaling, stem cells, stem cell maintenance, cell differentiation, tissue homeostasis, embryonic development, cell-to-cell signaling, comparative developmental biology, Drosophila, zebrafish, mice
- MeSH terms
- Animals, Cell Differentiation, Drosophila, Fishes, Homeostasis, Intestinal Mucosa, Intestines, Models, Biological, Muscles, Species Specificity, Stem Cells, Signal Transduction, Embryonic Development, Mice, Receptors, Notch
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