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Cell-autonomous action of the testis-determining gene: Sertoli cells are exclusively XY in XX ↔XY chimaeric mouse testes
Abstract
The distribution of XX and XY cells in XX ↔XY chimaeric mouse testes was analysed by enzyme marker analysis of separated testicular tissues and by in situ DNA marker analysis of air-dried testicular cells and testis sections. XX cells contributed to the Leydig cells, the peritubular cells and the vascularized connective tissue of the tunica albuginea. The Sertoli cells, on the other hand, appeared to be exclusively XY. These results indicate that during the development of the testis, Sertoli cell differentiation is triggered by cell-autonomous activity of the Y chromosomal testis-determining gene Tdy. Subsequent steps in testis differentiation may be a consequence of Sertoli cell activity.
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Citations
Cited by
A male-specific role for SOX9 in vertebrate sex determination
Kent, J., Wheatley, S. C., Andrews, J. E., Sinclair, A. H., & Koopman, P. (1996) · Development · doi:10.1242/dev.122.9.2813 · Cited by 710
Self-citationTemperature-Dependent Sex Determination in Vertebrates
(2018) · Open Monographs · doi:10.5479/si.9781944466213 · Cited by 522
Tevosian, S. G., Albrecht, K. H., Crispino, J. D., Fujiwara, Y., Eicher, E. M., & Orkin, S. H. (2002) · Development · doi:10.1242/dev.129.19.4627 · Cited by 369
XY female mice resulting from a heritable mutation in the primary testis determining gene, Tdy
Lovell-Badge, R., & Robertson, E. (1990) · Development · doi:10.1242/dev.109.3.635 · Cited by 311
The biochemical role of SRY in sex determination
R. Harley, V., & N. Goodfellow, P. (1994) · Molecular Reproduction and Development · doi:10.1002/mrd.1080390211 · Cited by 114
Metadata
- Authors
- Burgoyne, P. S., Buehr, M., Koopman, P., Rossant, J., & Mclaren, A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1988-02-01
- Volume
- 102
- Issue
- 2
- Pages
- 443-450
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2111121172
- Cited by
- 193
- References
- 0
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cell-autonomous action of the testis-determining gene: Sertoli cells are exclusively XY in XX ↔XY chimaeric mouse testes. https://app.cochat.ai/papers/10.1242/dev.102.2.443
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- Burgoyne, P. S., Buehr, M., Koopman, P., Rossant, J., & Mclaren, A. (1988). Cell-autonomous action of the testis-determining gene: Sertoli cells are exclusively XY in XX ↔XY chimaeric mouse testes. Development. https://doi.org/10.1242/dev.102.2.443
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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