Semaphorin signalling during development
Abstract
Semaphorins are secreted and membrane-associated proteins that regulate many different developmental processes, including neural circuit assembly, bone formation and angiogenesis. Trans and cis interactions between semaphorins and their multimeric receptors trigger intracellular signal transduction networks that regulate cytoskeletal dynamics and influence cell shape, differentiation, motility and survival. Here and in the accompanying poster we provide an overview of the molecular biology of semaphorin signalling within the context of specific cell and developmental processes, highlighting the mechanisms that act to fine-tune, diversify and spatiotemporally control the effects of semaphorins.
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Plexins and their cognate semaphorin ligands mediate a variety of cell-cell communications in development, adult physiology, and cancer.
“In addition to axon pathfinding during neurodevelopment, plexins and their cognate semaphorin ligands also mediate a variety of cell-cell communications in development, adult physiology, and cancer15–18.”
From Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease (2024) · cites this paper as [15]
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References 75 · Cited by 205
- Authors
- Jongbloets, B. C., & Pasterkamp, R. J.
- Affiliations
- University Medical Center Utrecht (NL)
- Corresponding author
- Pasterkamp, R. Jeroen
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2014-09-01
- Volume
- 141
- Issue
- 17
- Pages
- 3292-3297
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2139772609
- Cited by
- 205
- References
- 75
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 17 · 2023: 11 · 2022: 25 · 2021: 16 · 2020: 25 · 2019: 17 · 2018: 19 · 2017: 18 · 2016: 25 · 2015: 15
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- semaphorins, semaphorin receptors, signal transduction, neural circuit assembly, bone formation, angiogenesis, cytoskeletal dynamics, cell motility, cell differentiation, cell shape
- MeSH terms
- Animals, Humans, Receptors, Cell Surface, Time Factors, Signal Transduction, Semaphorins, Intracellular Space, Growth and Development
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