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Mechanisms of neurulation: traditional viewpoint and recent advances
Abstract
In this review article, the traditional viewpoint of how neurulation occurs is evaluated in light of recent advances. This has led to the formulation of the following fundamentals: (1) neurulation, specifically neural plate shaping and bending, is a multifactorial process resulting from forces both intrinsic and extrinsic to the neural plate; (2) neurulation is driven by both changes in neuroepithelial cell shape and other form-shaping events; and (3) forces for cell shape changes are generated by both the cytoskeleton and other factors. Several cell behaviors within the neural plate have been elucidated. Future challenges include identifying cell behaviors within non-neuroepithelial tissues, determining how intrinsic and extrinsic cell behaviors are orchestrated into coordinated morphogenetic movements and elucidating the molecular mechanisms underlying such behaviors.
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Cited by
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Eiraku, M., Takata, N., Ishibashi, H., Kawada, M., Sakakura, E., Okuda, S., Sekiguchi, K., Adachi, T., & Sasai, Y. (2011) · Nature · doi:10.1038/nature09941 · Cited by 2,001
Control of Cell Behavior During Vertebrate Development by Slug , a Zinc Finger Gene
Nieto, M. A., Sargent, M. G., Wilkinson, D. G., & Cooke, J. (1994) · Science · doi:10.1126/science.7513443 · Cited by 770
Yamada, T., Placzek, M., Tanaka, H., Dodd, J., & Jessell, T. M. (1991) · Cell · doi:10.1016/0092-8674(91)90247-v · Cited by 707
The genetic basis of mammalian neurulation
Copp, A. J., Greene, N. D. E., & Murdoch, J. N. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1181 · Cited by 697
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Hebrok, M., Kim, S. K., & Melton, D. A. (1998) · Genes & Development · doi:10.1101/gad.12.11.1705 · Cited by 628
Metadata
- Authors
- Schoenwolf, G. C., & Smith, J. L.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1990-06-01
- Volume
- 109
- Issue
- 2
- Pages
- 243-270
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1909841064
- Cited by
- 389
- References
- 0
- FWCI
- 8.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schoenwolf, G. C., & Smith, J. L. (1990). Mechanisms of neurulation: traditional viewpoint and recent advances. Development. https://doi.org/10.1242/dev.109.2.243
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
