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Cited by 447

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

A cytosolic sperm factor stimulates repetitive calcium increases and mimics fertilization in hamster eggs

Swann, Karl·1990·Development
DOI 10.1242/dev.110.4.1295
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Abstract

Microinjection of cytosolic sperm extracts into unfertilized golden hamster eggs caused a series of increases in cytoplasmic free calcium, Ca2+i, and membrane hyperpolarizing responses, HRs. These HRs and Ca2+i, transients are similar to those seen during in vitro fertilization of hamster eggs. The sperm factor that is responsible for causing these effects appears to be of high molecular weight and protein based. Injection of sperm factor activated eggs and mimicked fertilization in causing repetitive HRs in the presence of phorbol esters and in sensitizing the egg to calcium-induced calcium release. Since these effects cannot be mimicked by injecting G-protein agonists or calcium-containing solutions, it seems unlikely that a receptor-G-protein signalling system is involved at fertilization. These data instead suggest a novel signal transduction system operates during mammalian fertilization in which a protein factor is transferred from the sperm into the egg cytoplasm after gamete membrane fusion.

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Metadata

Authors
Swann, K.
Venue
Development
Publisher
The Company of Biologists
Published
1990-12-01
Volume
110
Issue
4
Pages
1295-1302
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.110.4.1295
OpenAlex
W1801735381
Cited by
447
References
13
FWCI
16.93
Type
journal article
Language
en
Open access
closed

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