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Cited by 225

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Cultured dermal papilla cells induce follicle formation and hair growth by transdifferentiation of an adult epidermis

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Reynolds, Amanda J., Jahoda, Colin A. B.·1992·Development

Abstract

Adult rat pelage follicle dermal papilla cells induced follicle neogenesis and external hair growth when associated with adult footpad skin epidermis. They thus demonstrated a capacity to completely change the structural arrangement and gene expression of adult epidermis - an ability previously undocumented for cultured adult cells. Isolation chambers ensured that de novo follicle formation must have occurred by eliminating the possibility of cellular contributions, and/or inductive influences, from local skin follicles. These findings argue against previous suggestions of vibrissa follicle specificity, and imply that the potential for hair follicle induction may be common to all adult papilla cells.

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Metadata

Authors
Reynolds, A. J., & Jahoda, C. A. B.
Venue
Development
Published
1992-06-01
Volume
115
Issue
2
Pages
587-593
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
OpenAlex
W2325218038
Cited by
225
References
0
FWCI
11.37
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Cultured dermal papilla cells induce follicle formation and hair growth by transdifferentiation of an adult epidermis. https://app.cochat.ai/papers/10.1242/dev.115.2.587
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Reynolds, A. J., & Jahoda, C. A. B. (1992). Cultured dermal papilla cells induce follicle formation and hair growth by transdifferentiation of an adult epidermis. Development. https://doi.org/10.1242/dev.115.2.587

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.