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Cited by 301

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Pattern formation in a secondary field: a hierarchy of regulatory genes subdivides the developing Drosophila wing disc into discrete subregions

Williams, Jim A., Paddock, Stephen W., Carroll, Sean B.·1993·Development
DOI 10.1242/dev.117.2.571
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Abstract

The legs and wings of insects and vertebrates develop from secondary embryonic fields that arise after the primary body axes have been established. In order to understand how the insect imaginal wing field is patterned, we have examined in detail the temporal and spatial expression patterns of, and epistatic relationships between, four key regulatory genes that are specifically required for wing formation in Drosophila. The wing less protein, in a role surprisingly distinct from its embryonic segment polarity function, appears to be the earliest-acting member of the hierarchy and crucial fordistinguishing the notum/wing subfields, and for the compartmentalization of the dorsal and ventral wing surfaces. The wingless product is required to restrict the expression of the apterous gene to dorsal cells and to promote the expression of the vestigial and scalloped genes that demarcate the wing primordia and act in concert to promote morphogenesis.

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Research works printed but not linked: 36

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Cited by

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Metadata

Authors
Williams, J. A., Paddock, S. W., & Carroll, S. B.
Venue
Development
Publisher
The Company of Biologists
Published
1993-02-01
Volume
117
Issue
2
Pages
571-584
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.117.2.571
OpenAlex
W2422481370
Cited by
301
References
0
FWCI
9.49
Type
journal article
Language
en
Open access
closed
Licence
www.biologists.com/user-licence-1-1/ (vor)

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CoChat. (2026). Citation check: Pattern formation in a secondary field: a hierarchy of regulatory genes subdivides the developing Drosophila wing disc into discrete subregions. https://app.cochat.ai/papers/10.1242/dev.117.2.571
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Williams, J. A., Paddock, S. W., & Carroll, S. B. (1993). Pattern formation in a secondary field: a hierarchy of regulatory genes subdivides the developing Drosophila wing disc into discrete subregions. Development. https://doi.org/10.1242/dev.117.2.571

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