The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice
Abstract
We have identified a model system for the study of pancreatic islet development and regeneration in transgenic mice bearing the interferon-gamma (IFN-g) gene expressed in the pancreatic islets. Previous studies showed that the locally produced IFN-g causes lymphocyte infiltration and islet cell destruction. Here we demonstrate that new islet cells are formed continuously from duct cells as evidenced by (1) the dramatic proliferation of duct cells, (2) the appearance of primitive cells and (3) their subsequent differentiation to endocrine cells. The IFN-g induced islet neogenesis is similar to embryonic islet morphogenesis and offers a model system for studying factors modulating islet development. Additionally, the duct cells occasionally transdifferentiate to gastrointestinal-like cell types and hepatocytes. These results underscore the lymphokine’s ability to initiate a complex ‘transdifferentiation’ pathway, providing a window for understanding lineage interrelationships within a terminally differentiated structure.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A severe combined immunodeficiency mutation in the mouse
Bosma, G. C., Custer, R. P., & Bosma, M. J. (1983) · Nature · doi:10.1038/301527a0 · Cited by 2,207
de Waal Malefyt, R., Haanen, J., Spits, H., Roncarolo, M. G., te Velde, A., Figdor, C., Johnson, K., Kastelein, R., Yssel, H., & de Vries, J. E. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.4.915 · Cited by 1,930
Oldstone, M. B. A., Nerenberg, M., Southern, P., Price, J., & Lewicki, H. (1991) · Cell · doi:10.1016/0092-8674(91)90165-u · Cited by 751
Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release.
Bonner-Weir, S., Trent, D. F., & Weir, G. C. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110910 · Cited by 467
Sarvetnick, N., Liggitt, D., Pitts, S. L., Hansen, S. E., & Stewart, T. A. (1988) · Cell · doi:10.1016/0092-8674(88)90414-x · Cited by 464
Self-citationAlpert, S., Hanahan, D., & Teitelman, G. (1988) · Cell · doi:10.1016/0092-8674(88)90391-1 · Cited by 452
Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ
Sarvetnick, N., Shizuru, J., Liggitt, D., Martin, L., Mclntyre, B., Gregory, A., Parslow, T., & Stewart, T. (1990) · Nature · doi:10.1038/346844a0 · Cited by 335
Self-citationLund, T., O'Reilly, L., Hutchings, P., Kanagawa, O., Simpson, E., Gravely, R., Chandler, P., Dyson, J., Picard, J. K., Edwards, A., et al. (1990) · Nature · doi:10.1038/345727a0 · Cited by 331
Responses of Neonatal Rat Islets to Streptozotocin: Limited B-Cell Regeneration and Hyperglycemia
Bonner-Weir, S., Trent, D. F., Honey, R. N., & Weir, G. C. (1981) · Diabetes · doi:10.2337/diab.30.1.64 · Cited by 324
Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene
Herrera, P.-L., Huarte, J., Sanvito, F., Meda, P., Orci, L., & Vassalli, J.-D. (1991) · Development · doi:10.1242/dev.113.4.1257 · Cited by 269
Cited by
A bipotential precursor population for pancreas and liver within the embryonic endoderm
Deutsch, G., Jung, J., Zheng, M., Lóra, J., & Zaret, K. S. (2001) · Development · doi:10.1242/dev.128.6.871 · Cited by 611
Yang, L., Li, S., Hatch, H., Ahrens, K., Cornelius, J. G., Petersen, B. E., & Peck, A. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122210699 · Cited by 494
Kopp, J. L., Dubois, C. L., Schaffer, A. E., Hao, E., Shih, H. P., Seymour, P. A., Ma, J., & Sander, M. (2011) · Development · doi:10.1242/dev.056499 · Cited by 469
Inada, A., Nienaber, C., Katsuta, H., Fujitani, Y., Levine, J., Morita, R., Sharma, A., & Bonner-Weir, S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805803105 · Cited by 448
Duct- to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats
Wang, R. N., Kl�ppel, G., & Bouwens, L. (1995) · Diabetologia · doi:10.1007/bf00400600 · Cited by 438
Regulation of pancreatic beta-cell mass
Bouwens, L., & Rooman, I. (2005) · Physiological Reviews · doi:10.1152/physrev.00025.2004 · Cited by 411
Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration
Jensen, J. N., Cameron, E., Garay, M. V. R., Starkey, T. W., Gianani, R., & Jensen, J. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.12.008 · Cited by 353
Life and Death of the Pancreatic β Cells
BONNERWEIR, S. (2000) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00305-2 · Cited by 277
Kiba, T. (2004) · Pancreas · doi:10.1097/00006676-200408000-00019 · Cited by 126
Metadata
- Authors
- Gu, D., & Sarvetnick, N.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1993-05-01
- Volume
- 118
- Issue
- 1
- Pages
- 33-46
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1958779837
- Cited by
- 321
- References
- 44
- FWCI
- 10.72
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
