The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Pax-2 is required for mesenchyme-to-epithelium conversion during kidney development
Abstract
The conversion of mesenchyme to epithelium during the embryonic development of the mammalian kidney requires reciprocal inductive interactions between the ureter and the responding metanephric mesenchyme. The Pax-2 gene is activated in the mesenchyme in response to induction and is subsequently down-regulated in more differentiated cells derived from the mesenchyme. Pax-2 belongs to a family of genes, at least three of which encode morphogenetic regulatory transcription factors. In order to determine the role of Pax-2 during kidney development, we have generated a loss-of-function phenotype using antisense oligonucleotides in mouse kidney organ cultures. These oligonucleotides can specifically inhibit Pax-2 protein accumulation in kidney mesenchyme cells, where the intracellular concentrations are maximal. The kidney organ cultures were stained with uvomurulin and laminin antibodies as markers for epithelium formation. With significantly reduced Pax-2 protein levels, kidney mesenchyme cells fail to aggregate and do not undergo the sequential morphological changes characteristic of epithelial cell formation. The data demonstrate that Pax-2 function is required for the earliest phase of mesenchyme-to-epithelium conversion.
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Cites
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Panayotou, G., End, P., Aumailley, M., Timpl, R., & Engel, J. (1989) · Cell · doi:10.1016/0092-8674(89)90987-2 · Cited by 341
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The basics of epithelial-mesenchymal transition
Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196
Cell biology of the glomerular podocyte
Pavenstädt, H., Kriz, W., & Kretzler, M. (2003) · Physiological Reviews · doi:10.1152/physrev.00020.2002 · Cited by 1,499
An Iron Delivery Pathway Mediated by a Lipocalin
Yang, J., Goetz, D., Li, J.-Y., Wang, W., Mori, K., Setlik, D., Du, T., Erdjument-Bromage, H., Tempst, P., Strong, R., et al. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00710-4 · Cited by 651
Methylation determines fibroblast activation and fibrogenesis in the kidney
Bechtel, W., McGoohan, S., Zeisberg, E. M., Müller, G. A., Kalbacher, H., Salant, D. J., Müller, C. A., Kalluri, R., & Zeisberg, M. (2010) · Nature Medicine · doi:10.1038/nm.2135 · Cited by 639
GFRα1 Is an Essential Receptor Component for GDNF in the Developing Nervous System and Kidney
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Metadata
- Authors
- Rothenpieler, U. W., & Dressler, G. R.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1993-11-01
- Volume
- 119
- Issue
- 3
- Pages
- 711-720
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2117606428
- Cited by
- 276
- References
- 1
- FWCI
- 4.12
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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