The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
pannier, a negative regulator of achaete and scute in Drosophila, encodes a zinc finger protein with homology to the vertebrate transcription factor GATA-1
Abstract
The gene pannier acts as a repressor of achaete and scute, two transcription factors expressed in discrete subsets of cells at the sites where neural precursors develop. Molecular analysis of mutant alleles revealed the presence of two functional domains within the pannier protein: a zinc finger domain showing homology to the GATA-1 family of vertebrate transcription factors and a domain comprising two putative amphipathic helices. Mutants associated with lesions in the zinc finger domain display an overexpression of achaete and scute and the development of extra neural precursors. Mutant proteins in which the domain including the putative helices is deleted act as hyperactive repressor molecules causing a loss of achaete/scute expression and a loss of neural precursors. Other results suggest that the activity of pannier may be modulated by association with position-specific factors.
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Cites
Pevny, L., Simon, M. C., Robertson, E., Klein, W. H., Tsai, S.-F., D'Agati, V., Orkin, S. H., & Costantini, F. (1991) · Nature · doi:10.1038/349257a0 · Cited by 1,308
Wall, L., deBoer, E., & Grosveld, F. (1988) · Genes & Development · doi:10.1101/gad.2.9.1089 · Cited by 350
Genetic control of sensory connections in Drosophila
Vandervorst, P., & Ghysen, A. (1980) · Nature · doi:10.1038/286065a0 · Cited by 116
Cited by
GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.
Laverriere, A. C., MacNeill, C., Mueller, C., Poelmann, R. E., Burch, J. B., & Evans, T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31636-8 · Cited by 558
Autoregulation and multiple enhancers control Math1 expression in the developing nervous system
Helms, A. W., Abney, A. L., Ben-Arie, N., Zoghbi, H. Y., & Johnson, J. E. (2000) · Development · doi:10.1242/dev.127.6.1185 · Cited by 289
Conservation of neurogenic genes and mechanisms
Chan, Y.-M., & Jan, Y. N. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00017-3 · Cited by 58
Metadata
- Authors
- Ramain, P., Heitzler, P., Haenlin, M., & Simpson, P.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1993-12-01
- Volume
- 119
- Issue
- 4
- Pages
- 1277-1291
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2132340881
- Cited by
- 221
- References
- 3
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: pannier, a negative regulator of achaete and scute in Drosophila, encodes a zinc finger protein with homology to the vertebrate transcription factor GATA-1. https://app.cochat.ai/papers/10.1242/dev.119.4.1277
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- Ramain, P., Heitzler, P., Haenlin, M., & Simpson, P. (1993). pannier, a negative regulator of achaete and scute in Drosophila, encodes a zinc finger protein with homology to the vertebrate transcription factor GATA-1. Development. https://doi.org/10.1242/dev.119.4.1277
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
