Adding a spatial dimension to postnatal ventricular-subventricular zone neurogenesis
Abstract
Neurogenesis does not stop abruptly at birth, but persists in specific brain regions throughout life. The neural stem cells (NSCs) located in the largest germinal region of the forebrain, the ventricular-subventricular zone (V-SVZ), replenish olfactory neurons throughout life. However, V-SVZ NSCs are heterogeneous: they have different embryonic origins and give rise to distinct neuronal subtypes depending on their location. In this Review, we discuss how this spatial heterogeneity arises, how it affects NSC biology, and why its consideration in future studies is crucial for understanding general principles guiding NSC self-renewal, differentiation and specification.
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V-SVZ NSCs give rise to specific subtypes of olfactory bulb interneurons or glia depending on their spatial location.
“Importantly, V-SVZ NSCs have a regional identity and give rise to specific subtypes of olfactory bulb interneurons or glia depending on their spatial location (Chaker et al., 2016; Fiorelli et al., 2015).”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Fiorelli et al., 2015
V-SVZ NSCs have a regional identity.
“Importantly, V-SVZ NSCs have a regional identity and give rise to specific subtypes of olfactory bulb interneurons or glia depending on their spatial location (Chaker et al., 2016; Fiorelli et al., 2015).”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Fiorelli et al., 2015
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References 102 · Cited by 116
- Authors
- Fiorelli, R., Azim, K., Fischer, B., & Raineteau, O.
- Affiliations
- Barrow Neurological Institute (US)
- University of Zurich (CH)
- Lyon 1 Université (FR)
- Corresponding author
- Raineteau, Olivier
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2015-06-15
- Volume
- 142
- Issue
- 12
- Pages
- 2109-2120
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2292471654
- Cited by
- 116
- References
- 102
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 9 · 2023: 7 · 2022: 9 · 2021: 8 · 2020: 15 · 2019: 15 · 2018: 12 · 2017: 15 · 2016: 12 · 2015: 2
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Council
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- ventricular-subventricular zone, postnatal neurogenesis, neural stem cells, spatial heterogeneity, olfactory bulb, self-renewal, neuronal differentiation, neuronal specification, embryonic origin
- MeSH terms
- Humans, Prosencephalon, Body Patterning, Lateral Ventricles, Neurogenesis, Neural Stem Cells
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