The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Expression of baculovirus P35 prevents cell death in Drosophila
Abstract
The baculovirus P35 protein functions to prevent apoptotic death of infected cells. We have expressed P35 in the developing embryo and eye of the fly Drosophila melanogaster. P35 eliminates most, if not all, normally occurring cell death in these tissues, as well as X-irradiation-induced death. Excess pupal eye cells that are normally eliminated by apoptosis develop into pigment cells when their death is prevented by P35 expression. Our results suggest that one mechanism by which viruses prevent the death of the host cell is to block a cell death pathway that mediates normally occurring cell death. Identification of molecules that interact biochemically or genetically with P35 in Drosophila should provide important insights into how cell death is regulated.
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Cites
p53 is required for radiation-induced apoptosis in mouse thymocytes
Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864
Cited by
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
Clark, I. E., Dodson, M. W., Jiang, C., Cao, J. H., Huh, J. R., Seol, J. H., Yoo, S. J., Hay, B. A., & Guo, M. (2006) · Nature · doi:10.1038/nature04779 · Cited by 1,788
Self-citationLife, death, and the pursuit of apoptosis.
White, E. (1996) · Genes & Development · doi:10.1101/gad.10.1.1 · Cited by 1,311
Brogiolo, W., Stocker, H., Ikeya, T., Rintelen, F., Fernandez, R., & Hafen, E. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00068-9 · Cited by 1,255
Rothe, M., Pan, M.-G., Henzel, W. J., Ayres, T. M., & V. Goeddel, D. (1995) · Cell · doi:10.1016/0092-8674(95)90149-3 · Cited by 1,253
The head involution defective gene of Drosophila melanogaster functions in programmed cell death.
Grether, M. E., Abrams, J. M., Agapite, J., White, K., & Steller, H. (1995) · Genes & Development · doi:10.1101/gad.9.14.1694 · Cited by 699
Metadata
- Authors
- Hay, B. A., Wolff, T., & Rubin, G. M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1994-08-01
- Volume
- 120
- Issue
- 8
- Pages
- 2121-2129
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2139587743
- Cited by
- 1,066
- References
- 1
- FWCI
- 13.48
- Type
- journal article
- Language
- en
- Open access
- closed
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