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Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development
Abstract
To address the function of bone morphogenetic protein-2 (BMP2) in mammalian development, mice with a targeted deletion of the Bmp2 mature region were generated using embryonic stem cell technology. This mutation caused embryonic lethality when homozygous. Mutant embryos failed to close the proamniotic canal, which caused the malformation of the amnion/chorion. BMP2-deficient embryos also exhibited a defect in cardiac development, manifested by the abnormal development of the heart in the exocoelomic cavity. These defects are consistent with the expression of Bmp2 in the extraembryonic mesoderm cells and promyocardium. Thus BMP2 is a critical factor for both extraembryonic and embryonic development.
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Cited by
BMP signalling in skeletal development, disease and repair
Salazar, V. S., Gamer, L. W., & Rosen, V. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.12 · Cited by 822
Bone morphogenetic proteins: a critical review
Bragdon, B., Moseychuk, O., Saldanha, S., King, D., Julian, J., & Nohe, A. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2010.10.003 · Cited by 691
Developmental system drift and flexibility in evolutionary trajectories
True, J. R., & Haag, E. S. (2001) · Evolution & Development · doi:10.1046/j.1525-142x.2001.003002109.x · Cited by 678
Genetic Analysis of the Roles of BMP2, BMP4, and BMP7 in Limb Patterning and Skeletogenesis
Bandyopadhyay, A., Tsuji, K., Cox, K., Harfe, B. D., Rosen, V., & Tabin, C. J. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020216 · Cited by 624
Id Genes Are Direct Targets of Bone Morphogenetic Protein Induction in Embryonic Stem Cells
Hollnagel, A., Oehlmann, V., Heymer, J., Rüther, U., & Nordheim, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19838 · Cited by 527
Metadata
- Authors
- Zhang, H., & Bradley, A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1996-10-01
- Volume
- 122
- Issue
- 10
- Pages
- 2977-2986
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1937940610
- Cited by
- 983
- References
- 0
- FWCI
- 11.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, H., & Bradley, A. (1996). Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development. https://doi.org/10.1242/dev.122.10.2977
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
