The DOI matches its Crossref record.
Ectopic expression of Hoxa-1 in the zebrafish alters the fate of the mandibular arch neural crest and phenocopies a retinoic acid-induced phenotype
Abstract
Considerable evidence has demonstrated that retinoic acid influences the formation of the primary body axis in vertebrates and that this may occur through the regulation of Hox gene expression. In this study, we show that the phenotype induced by exogenous retinoic acid in the zebrafish can also be generated by the overexpression of Hoxa-1 following injection of synthetic RNA into the fertilised egg. The isolation, sequence and expression pattern of the zebrafish Hoxa-1 gene is described. We show that exogenously applied retinoic acid causes the ectopic accumulation of Hoxa-1 message during gastrulation in the hypoblast in the head region. Overexpression of Hoxa-1 following injection of RNA causes abnormal growth of the anterior hindbrain, duplication of Mauthner neurons in rhombomere (r) 2 and fate changes of r2 mesenchymal and neurogenic neural crest. These results are discussed in terms of the role of Hoxa-1 in controlling anterior hindbrain patterning and the relationship between expression of Hoxa-1 and retinoic acid.
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Cited by
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Barth, K. A., Kishimoto, Y., Rohr, K. B., Seydler, C., Schulte-Merker, S., & Wilson, S. W. (1999) · Development · doi:10.1242/dev.126.22.4977 · Cited by 269
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Fraser, G. J., Hulsey, C. D., Bloomquist, R. F., Uyesugi, K., Manley, N. R., & Streelman, J. T. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000031 · Cited by 228
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Metadata
- Authors
- Alexandre, D., Clarke, J. D. W., Oxtoby, E., Yan, Y.-L., Jowett, T., & Holder, N.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1996-03-01
- Volume
- 122
- Issue
- 3
- Pages
- 735-746
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2276715922
- Cited by
- 199
- References
- 0
- FWCI
- 6.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Ectopic expression of Hoxa-1 in the zebrafish alters the fate of the mandibular arch neural crest and phenocopies a retinoic acid-induced phenotype. https://app.cochat.ai/papers/10.1242/dev.122.3.735
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- Alexandre, D., Clarke, J. D. W., Oxtoby, E., Yan, Y.-L., Jowett, T., & Holder, N. (1996). Ectopic expression of Hoxa-1 in the zebrafish alters the fate of the mandibular arch neural crest and phenocopies a retinoic acid-induced phenotype. Development. https://doi.org/10.1242/dev.122.3.735
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