Stomach development, stem cells and disease
Open accessAbstract
The stomach, an organ derived from foregut endoderm, secretes acid and enzymes and plays a key role in digestion. During development, mesenchymal-epithelial interactions drive stomach specification, patterning, differentiation and growth through selected signaling pathways and transcription factors. After birth, the gastric epithelium is maintained by the activity of stem cells. Developmental signals are aberrantly activated and stem cell functions are disrupted in gastric cancer and other disorders. Therefore, a better understanding of stomach development and stem cells can inform approaches to treating these conditions. This Review highlights the molecular mechanisms of stomach development and discusses recent findings regarding stomach stem cells and organoid cultures, and their roles in investigating disease mechanisms.
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EMIs drive stomach specification, kidney duct patterning, lung development, lacrimal gland bud formation, and teeth bud formation.
“For example, EMIs drive stomach specification (1), duct patterning of the kidney (2) and lung (3), and bud formation of the lacrimal gland (4) and teeth (5).”
From Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction (2022) · cites this paper as [1]
Epithelial-mesenchymal interactions trigger the development of various tissues and organs through specific signaling pathways and transcription factors.
“During the early developmental stages, epithelial-mesenchymal interactions (EMIs) trigger the development of various tissues and organs through specific signaling pathways and transcription factors.”
From Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction (2022) · cites this paper as [1]
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References 142 · Cited by 175
- Authors
- Kim, T.-H., & Shivdasani, R. A.
- Affiliations
- University of Toronto (CA)
- Brigham and Women's Hospital (US)
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2016-02-15
- Volume
- 143
- Issue
- 4
- Pages
- 554-565
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- PMC
- PMC4760317
- OpenAlex
- W2292396958
- Cited by
- 175
- References
- 142
- Citations by year
- 2026: 15 · 2025: 17 · 2024: 22 · 2023: 14 · 2022: 23 · 2021: 15 · 2020: 17 · 2019: 11 · 2018: 24 · 2017: 14 · 2016: 3
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Institutes of Health (R01DK081113)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Digestive system and related health
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- stomach development, gastric stem cells, gastric epithelium, epithelial-mesenchymal interactions, foregut endoderm, signaling pathways, transcription factors, gastric cancer, organoid culture, organogenesis
- MeSH terms
- Animals, Endoderm, Humans, Stem Cells, Stomach, Stomach Diseases, Signal Transduction, Body Patterning
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