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Cell proliferation control by Notch signaling in Drosophila development
Abstract
The Notch receptor mediates cell interactions controlling the developmental fate of a broad spectrum of undifferentiated cells. By modulating Notch signaling in specific precursor cells during Drosophila imaginal disc development, we demonstrate that Notch activity can influence cell proliferation. The activation of the Notch receptor in the wing disc induces the expression of the wing margin patterning genes vestigial and wingless, and strong mitotic activity. However, the effect of Notch signaling on cell proliferation is not the simple consequence of the upregulation of either vestigial or wingless. Vestigial and Wingless, on the contrary, display synergistic effects with Notch signaling, resulting in the stimulation of cell proliferation in imaginal discs.
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Citations
Cited by
Notch Signaling: Cell Fate Control and Signal Integration in Development
Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909
Self-citationBrennecke, J., Hipfner, D. R., Stark, A., Russell, R. B., & Cohen, S. M. (2003) · Cell · doi:10.1016/s0092-8674(03)00231-9 · Cited by 2,042
scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila
Brumby, A. M., & Richardson, H. E. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg548 · Cited by 628
p27Kip1 links cell proliferation to morphogenesis in the developing organ of Corti
Chen, P., & Segil, N. (1999) · Development · doi:10.1242/dev.126.8.1581 · Cited by 555
Metadata
- Authors
- Go, M. J., Eastman, D. S., & Artavanis-Tsakonas, S.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1998-06-01
- Volume
- 125
- Issue
- 11
- Pages
- 2031-2040
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2168948134
- Cited by
- 273
- References
- 0
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Go, M. J., Eastman, D. S., & Artavanis-Tsakonas, S. (1998). Cell proliferation control by Notch signaling in Drosophila development. Development. https://doi.org/10.1242/dev.125.11.2031
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