The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Oocyte polarity depends on regulation of gurken by Vasa
Abstract
Vasa, a DEAD box mRNA helicase similar to eIF4A, is involved in pole plasm assembly in the Drosophila oocyte and appears to regulate translation of oskar and nanos mRNAs. However, several vasa alleles exhibit a wide range of early oogenesis phenotypes. Here we report a detailed analysis of Vasa function during early oogenesis using novel as well as previously identified hypomorphic vasa alleles. We find that vasa is required for the establishment of both anterior-posterior and dorsal-ventral polarity of the oocyte. The polarity defects of vasa mutants appear to be caused by a reduction in the amount of Gurken protein at stages of oogenesis critical for the establishment of polarity. Vasa is required for translation of gurken mRNA during early oogenesis and for achieving wild-type levels of gurken mRNA expression later in oogenesis. A variety of early oogenesis phenotypes observed in vasa ovaries, which cannot be attributed to the defect in gurken expression, suggest that vasa also affects expression of other mRNAs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Schüpbach, T. (1987) · Cell · doi:10.1016/0092-8674(87)90546-0 · Cited by 367
Cited by
Structural Basis for RNA Unwinding by the DEAD-Box Protein Drosophila Vasa
Sengoku, T., Nureki, O., Nakamura, A., Kobayashi, S., & Yokoyama, S. (2006) · Cell · doi:10.1016/j.cell.2006.01.054 · Cited by 573
Toyooka, Y., Tsunekawa, N., Takahashi, Y., Matsui, Y., Satoh, M., & Noce, T. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00283-5 · Cited by 548
Nakamura, A., Amikura, R., Hanyu, K., & Kobayashi, S. (2001) · Development · doi:10.1242/dev.128.17.3233 · Cited by 334
mRNA helicases: the tacticians of translational control
Parsyan, A., Svitkin, Y., Shahbazian, D., Gkogkas, C., Lasko, P., Merrick, W. C., & Sonenberg, N. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3083 · Cited by 323
Axis formation during Drosophila oogenesis
Riechmann, V., & Ephrussi, A. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00207-0 · Cited by 274
Self-citation
Metadata
- Authors
- Tomancak, P., Guichet, A., Zavorszky, P., & Ephrussi, A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1998-05-01
- Volume
- 125
- Issue
- 9
- Pages
- 1723-1732
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2143647123
- Cited by
- 189
- References
- 1
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
