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Eph receptors and ephrins: effectors of morphogenesis
Abstract
Eph receptor tyrosine kinases and their ligands, the ephrins, appear to lie functionally at the interface between pattern formation and morphogenesis. We review the role of Eph and ephrin signalling in the formation of segmented structures, in the control of axon guidance and cell migration and in the development of the vasculature. We address the question of how the specificity of response is achieved and discuss the specificity of ephrin-Eph interactions and the significance of structural domains in Eph receptors.
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Metadata
- Authors
- Holder, N., & Klein, R.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1999-05-15
- Volume
- 126
- Issue
- 10
- Pages
- 2033-2044
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2185351394
- Cited by
- 442
- References
- 0
- FWCI
- 19.13
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
