The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Building the heart piece by piece: modularity of cis-elements regulating Nkx2-5 transcription
Abstract
Heart formation in Drosophila is dependent on the homeobox gene tinman. The homeobox gene Nkx2-5 is closely related to tinman and is the earliest known marker for cardiogenesis in vertebrate embryos. Recent studies of cis-regulatory elements required for Nkx2-5 expression in the developing mouse heart have revealed an extraordinary array of independent cardiac enhancers, and associated negative regulatory elements, that direct transcription in distinct regions of the embryonic heart. These studies demonstrate the modularity in cardiac transcription, in which different regulatory elements respond to distinct sets of transcription factors to control gene expression in different compartments of the developing heart. We consider the potential mechanisms underlying such transcriptional complexity, its possible significance for cardiac function, and the implications for evolution of the multichambered heart.
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GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.
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Metadata
- Authors
- Schwartz, R. J., & Olson, E. N.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1999-10-01
- Volume
- 126
- Issue
- 19
- Pages
- 4187-4192
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2114748673
- Cited by
- 185
- References
- 2
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
