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Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages
Open accessAbstract
To analyze cell lineage in the pancreatic islets, we have irreversibly tagged all the progeny of cells through the activity of Cre recombinase. Adult glucagon (α) and insulin (β) cells are shown to derive from cells that have never transcribed insulin or glucagon, respectively. Also, the β-cell progenitors, but not α-cell progenitors, transcribe the pancreatic polypeptide (PP) gene. Finally, the homeodomain gene PDX1, which is expressed by adult β-cells, is also expressed by α-cell progenitors. Thus the islet α- and β-cell lineages appear to arise independently during ontogeny, probably from a common precursor.
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Cited by
Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure
Talchai, C., Xuan, S., Lin, H. V., Sussel, L., & Accili, D. (2012) · Cell · doi:10.1016/j.cell.2012.07.029 · Cited by 1,415
Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss
Thorel, F., Népote, V., Avril, I., Kohno, K., Desgraz, R., Chera, S., & Herrera, P. L. (2010) · Nature · doi:10.1038/nature08894 · Cited by 1,136
Self-citationThe role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
Kawaguchi, Y., Cooper, B., Gannon, M., Ray, M., MacDonald, R. J., & Wright, C. V. E. (2002) · Nature Genetics · doi:10.1038/ng959 · Cited by 1,007
Opposing actions of Arx and Pax4 in endocrine pancreas development
Collombat, P., Mansouri, A., Hecksher-Sørensen, J., Serup, P., Krull, J., Gradwohl, G., & Gruss, P. (2003) · Genes & Development · doi:10.1101/gad.269003 · Cited by 600
Recovery from diabetes in mice by β cell regeneration
Nir, T., Melton, D. A., & Dor, Y. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32959 · Cited by 595
Metadata
- Authors
- Herrera, P. L.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2000-06-01
- Volume
- 127
- Issue
- 11
- Pages
- 2317-2322
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2136585808
- Cited by
- 672
- References
- 0
- FWCI
- 23.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Herrera, P. L. (2000). Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development. https://doi.org/10.1242/dev.127.11.2317
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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