The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels
Abstract
The zebrafish mutant violet beauregarde (vbg) can be identified at two days post-fertilization by an abnormal circulation pattern in which most blood cells flow through a limited number of dilated cranial vessels and fail to perfuse the trunk and tail. This phenotype cannot be explained by caudal vessel abnormalities or by a defect in cranial vessel patterning, but instead stems from an increase in endothelial cell number in specific cranial vessels. We show that vbg encodes activin receptor-like kinase 1 (Acvrl1; also known as Alk1), a TGFβ type I receptor that is expressed predominantly in the endothelium of the vessels that become dilated in vbg mutants. Thus, vbg provides a model for the human autosomal dominant disorder, hereditary hemorrhagic telangiectasia type 2, in which disruption of ACVRL1 causes vessel malformations that may result in hemorrhage or stroke. Movies available on-line
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Cites
Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice
Dickson, M. C., Martin, J. S., Cousins, F. M., Kulkarni, A. B., Karlsson, S., & Akhurst, R. J. (1995) · Development · doi:10.1242/dev.121.6.1845 · Cited by 1,029
Cited by
Dejana, E., Tournier-Lasserve, E., & Weinstein, B. M. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.004 · Cited by 788
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Larrivée, B., Prahst, C., Gordon, E., del Toro, R., Mathivet, T., Duarte, A., Simons, M., & Eichmann, A. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.02.005 · Cited by 359
Wooderchak-Donahue, W. L., McDonald, J., O’Fallon, B., Upton, P. D., Li, W., Roman, B. L., Young, S., Plant, P., Fülöp, G. T., Langa, C., et al. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.07.004 · Cited by 305
Self-citationEndothelial Cilia Mediate Low Flow Sensing during Zebrafish Vascular Development
Goetz, J. G., Steed, E., Ferreira, R. R., Roth, S., Ramspacher, C., Boselli, F., Charvin, G., Liebling, M., Wyart, C., Schwab, Y., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.01.032 · Cited by 219
ALK1 as an emerging target for antiangiogenic therapy of cancer.
Cunha, S. I., & Pietras, K. (2011) · Blood · doi:10.1182/blood-2011-01-330142 · Cited by 184
Metadata
- Authors
- Roman, B. L., Pham, V. N., Lawson, N. D., Kulik, M., Childs, S., Lekven, A. C., Garrity, D. M., Moon, R. T., Fishman, M. C., Lechleider, R. J., & Weinstein, B. M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2002-06-15
- Volume
- 129
- Issue
- 12
- Pages
- 3009-3019
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2117400715
- Cited by
- 365
- References
- 1
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
