The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2
Abstract
In mammals, Sry expression in the bipotential, undifferentiated gonad directs the support cell precursors to differentiate as Sertoli cells, thus initiating the testis differentiation pathway. In the absence of Sry, or if Sry is expressed at insufficient levels, the support cell precursors differentiate as granulosa cells, thus initiating the ovarian pathway. The molecular mechanisms upstream and downstream of Sry are not well understood. We demonstrate that the transcription factor GATA4 and its co-factor FOG2 are required for gonadal differentiation. Mouse fetuses homozygous for a null allele of Fog2 or homozygous for a targeted mutation in Gata4 (Gata4ki) that abrogates the interaction of GATA4 with FOG co-factors exhibit abnormalities in gonadogenesis. We found that Sry transcript levels were significantly reduced in XY Fog2–/– gonads at E11.5, which is the time when Sry expression normally reaches its peak. In addition, three genes crucial for normal Sertoli cell function (Sox9, Mis and Dhh) and three Leydig cell steroid biosynthetic enzymes (p450scc, 3βHSD and p450c17) were not expressed in XY Fog2–/– and Gataki/ki gonads, whereas Wnt4, a gene required for normal ovarian development, was expressed ectopically. By contrast, Wt1 and Sf1, which are expressed prior to Sry and necessary for gonad development in both sexes, were expressed normally in both types of mutant XY gonads. These results indicate that GATA4 and FOG2 and their physical interaction are required for normal gonadal development.
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Cites
Male development of chromosomally female mice transgenic for Sry
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WT-1 is required for early kidney development
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Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene
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Female development in mammals is regulated by Wnt-4 signalling
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Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.
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SOX9 Is a Potent Activator of the Chondrocyte-Specific Enhancer of the Proα1(II) Collagen Gene
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GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.
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The Zinc Finger-containing Transcription Factors GATA-4, -5, and -6
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Cited by
Sex Determination and Gonadal Development in Mammals
Wilhelm, D., Palmer, S., & Koopman, P. (2007) · Physiological Reviews · doi:10.1152/physrev.00009.2006 · Cited by 686
One tissue, two fates: molecular genetic events that underlie testis versus ovary development
Brennan, J., & Capel, B. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1381 · Cited by 549
Amberg, J. J., Goforth, R. R., & Sepúlveda, M. S. (2013) · Sexual Development · doi:10.1159/000354280 · Cited by 477
Sry: the master switch in mammalian sex determination
Kashimada, K., & Koopman, P. (2010) · Development · doi:10.1242/dev.048983 · Cited by 351
Sex determination, gonadal sex differentiation, and plasticity in vertebrate species
Nagahama, Y., Chakraborty, T., Paul-Prasanth, B., Ohta, K., & Nakamura, M. (2021) · Physiological Reviews · doi:10.1152/physrev.00044.2019 · Cited by 346
Sex determination and SRY: down to a wink and a nudge?
Sekido, R., & Lovell-Badge, R. (2009) · Trends in Genetics · doi:10.1016/j.tig.2008.10.008 · Cited by 316
Role of the GATA Family of Transcription Factors in Endocrine Development, Function, and Disease
Viger, R. S., Guittot, S. M., Anttonen, M., Wilson, D. B., & Heikinheimo, M. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0513 · Cited by 270
Bland, M. L., Fowkes, R. C., & Ingraham, H. A. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0333 · Cited by 105
Metadata
- Authors
- Tevosian, S. G., Albrecht, K. H., Crispino, J. D., Fujiwara, Y., Eicher, E. M., & Orkin, S. H.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2002-10-01
- Volume
- 129
- Issue
- 19
- Pages
- 4627-4634
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2155519853
- Cited by
- 369
- References
- 64
- FWCI
- 8.67
- Type
- journal article
- Language
- en
- Open access
- closed
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