Development of the mammalian main olfactory bulb
Open accessAbstract
The mammalian main olfactory bulb is a crucial processing centre for the sense of smell. The olfactory bulb forms early during development and is functional from birth. However, the olfactory system continues to mature and change throughout life as a target of constitutive adult neurogenesis. Our Review synthesises current knowledge of prenatal, postnatal and adult olfactory bulb development, focusing on the maturation, morphology, functions and interactions of its diverse constituent glutamatergic and GABAergic cell types. We highlight not only the great advances in the understanding of olfactory bulb development made in recent years, but also the gaps in our present knowledge that most urgently require addressing.
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There is relatedness between the Cajal-Retzius cells mostly found in HPF (subclass 036 HPF CR Glut) and the olfactory bulb glutamatergic subclass 035 OB Eomes Ms4a15 Glut, which are likely mitral and tufted cells, and they are grouped into the OB-CR Glut class.
“In addition, we uncovered relatedness between the Cajal–Retzius (CR) cells mostly found in HPF (subclass 036 HPF CR Glut) and the olfactory bulb (OB) glutamatergic subclass, 035 OB Eomes Ms4a15 Glut, which are likely mitral and tufted cells28, and grouped them into the OB–CR Glut class (Extended Data Fig. 6).”
From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [28]
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References 246 · Cited by 75
Research works printed but not linked: 2
- Fujimoto, S., Leiwe, M. N., Sakaguchi, R., Muroyama, Y., Kobayakawa, R., Kobayakawa, K., Saito, T. and Imai, T. (2019). Spontaneous activity generated within the olfactory bulb establishes the discrete wiring of mitral cell dendrites. bioRxiv, 625616.
- Su, X., Kovalchuk, Y., Mojtahedi, N. and Garaschuk, O. (2020). Enhanced ongoing endogenous activity predicts elimination of adult-born neurons in the mouse olfactory bulb. bioRxiv, 2020.09.09.286591.
- Authors
- Tufo, C., Poopalasundaram, S., Dorrego-Rivas, A., Ford, M. C., Graham, A., & Grubb, M. S.
- Affiliations
- King's College London (GB)
- Corresponding author
- Grubb, Matthew S.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2022-02-01
- Volume
- 149
- Issue
- 3
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- PMC
- PMC8918810
- OpenAlex
- W4211040428
- Cited by
- 75
- References
- 246
- Citations by year
- 2026: 9 · 2025: 21 · 2024: 24 · 2023: 16 · 2022: 5
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Development (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, other-oa)
- Funders
- Horizon 2020 (725729)
- Biotechnology and Biological Sciences Research Council (BB/V000195/1)
- King's College London
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- olfactory bulb development, olfactory system, prenatal development, postnatal development, adult neurogenesis, glutamatergic neurons, GABAergic neurons, olfaction
- MeSH terms
- Animals, Axons, Olfactory Bulb, Synapses, Signal Transduction, Olfactory Receptor Neurons, Bone Morphogenetic Proteins, Neurogenesis
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