Rats!
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The rat has potential for geroscience research because its aging physiology is closer to humans than mice, especially for onset of certain age-related conditions, and its larger size permits serial sampling and imaging not feasible in mice.
“However, the rat has tremendous potential for use in geroscience research, owning to its aging physiology being closer to humans compared to mice, especially with respect to onset of certain age-related conditions, as well as its larger size, which permits serial sampling and imaging studies not feasible in the mouse [36–41].”
From Reducing Senescent Cell Burden in Aging and Disease (2020) · cites this paper as [38]
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References 14 · Cited by 242
- Authors
- Iannaccone, P. M., & Jacob, H. J.
- Affiliations
- Northwestern University (US)
- Department of Physiology, Pediatrics, and Human and Molecular Genetics Center, Medical College of Milwaukee, WI 53226, USA
- ORCID
- Jacob, Howard J.
- Venue
- Disease Models & Mechanisms
- Publisher
- The Company of Biologists
- Published
- 2009-04-30
- Volume
- 2
- Issue
- 5-6
- Pages
- 206-210
- ISSN
- 1754-8403 (ISSN-L)
- 1754-8411
- PMC
- PMC2675817
- OpenAlex
- W4255166647
- Cited by
- 242
- References
- 14
- Citations by year
- 2026: 1 · 2025: 15 · 2024: 20 · 2023: 13 · 2022: 19 · 2021: 29 · 2020: 29 · 2019: 30 · 2018: 21 · 2017: 21 · 2016: 22 · 2015: 10 · 2014: 3 · 2013: 1 · 2012: 4
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Disease Models & Mechanisms (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Physical Sciences › Environmental Science › Ecology › Animal Ecology and Behavior Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Yersinia bacterium, plague, ectoparasites research
- Keywords
- rats
- MeSH terms
- Animals, Disease Models, Animal, Humans, Mice, Rats, Embryonic Stem Cells
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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