The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Mouse models of graft-versus-host disease: advances and limitations
Open accessAbstract
The limiting factor for successful hematopoietic stem cell transplantation (HSCT) is graft-versus-host disease (GvHD), a post-transplant disorder that results from immune-mediated attack of recipient tissue by donor T cells contained in the transplant. Mouse models of GvHD have provided important insights into the pathophysiology of this disease, which have helped to improve the success rate of HSCT in humans. The kinetics with which GvHD develops distinguishes acute from chronic GvHD, and it is clear from studies of mouse models of GvHD (and studies of human HSCT) that the pathophysiology of these two forms is also distinct. Mouse models also further the basic understanding of the immunological responses involved in GvHD pathology, such as antigen recognition and presentation, the involvement of the thymus and immune reconstitution after transplantation. In this Perspective, we provide an overview of currently available mouse models of acute and chronic GvHD, highlighting their benefits and limitations, and discuss research and clinical opportunities for the future.
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Cites
Of Mice and Not Men: Differences between Mouse and Human Immunology
Mestas, J., & Hughes, C. C. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2731 · Cited by 3,822
Fibrotic disease and the TH1/TH2 paradigm
Wynn, T. A. (2004) · Nature Reviews Immunology · doi:10.1038/nri1412 · Cited by 1,765
Probiotic effects on experimental graft-versus-host disease: let them eat yogurt
Gerbitz, A., Schultz, M., Wilke, A., Linde, H.-J., Schölmerich, J., Andreesen, R., & Holler, E. (2004) · Blood · doi:10.1182/blood-2003-11-3769 · Cited by 186
Cited by
Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation
Jenq, R. R., Ubeda, C., Taur, Y., Menezes, C. C., Khanin, R., Dudakov, J. A., Liu, C., West, M. L., Singer, N. V., Equinda, M. J., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20112408 · Cited by 626
Cooke, K. R., Luznik, L., Sarantopoulos, S., Hakim, F. T., Jagasia, M., Fowler, D. H., van den Brink, M. R. M., Hansen, J. A., Parkman, R., Miklos, D. B., et al. (2017) · Biology of Blood and Marrow Transplantation · doi:10.1016/j.bbmt.2016.09.023 · Cited by 472
Pluripotent stem cells progressing to the clinic
Trounson, A., & DeWitt, N. D. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.10 · Cited by 379
Chronic graft-versus-host disease: biological insights from preclinical and clinical studies
MacDonald, K. P. A., Hill, G. R., & Blazar, B. R. (2017) · Blood · doi:10.1182/blood-2016-06-686618 · Cited by 300
Fibrosing connective tissue disorders of the skin: Molecular similarities and distinctions
Canady, J., Karrer, S., Fleck, M., & Bosserhoff, A. K. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.03.005 · Cited by 66
Metadata
- Authors
- Schroeder, M. A., & DiPersio, J. F.
- Venue
- Disease Models & Mechanisms
- Publisher
- The Company of Biologists
- Published
- 2011-05-01
- Volume
- 4
- Issue
- 3
- Pages
- 318-333
- ISSN
- 1754-8403 (ISSN-L)
- 1754-8411
- OpenAlex
- W2151536540
- Cited by
- 291
- References
- 3
- FWCI
- 8.30
- Type
- journal article
- Language
- en
- Open access
- gold
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