The DOI matches its Crossref record; 167 of the 167 references it cites were found in a registry or an index.
Disease modelling in human organoids
Open accessAbstract
The past decade has seen an explosion in the field of in vitro disease modelling, in particular the development of organoids. These self-organizing tissues derived from stem cells provide a unique system to examine mechanisms ranging from organ development to homeostasis and disease. Because organoids develop according to intrinsic developmental programmes, the resultant tissue morphology recapitulates organ architecture with remarkable fidelity. Furthermore, the fact that these tissues can be derived from human progenitors allows for the study of uniquely human processes and disorders. This article and accompanying poster highlight the currently available methods, particularly those aimed at modelling human biology, and provide an overview of their capabilities and limitations. We also speculate on possible future technological advances that have the potential for great strides in both disease modelling and future regenerative strategies.
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Cites
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Self-citationSystematic identification of genomic markers of drug sensitivity in cancer cells
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Cited by
Human organoids: model systems for human biology and medicine
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Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution
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Cardioids reveal self-organizing principles of human cardiogenesis
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Metadata
- Authors
- Lancaster, M. A., & Huch, M.
- Venue
- Disease Models & Mechanisms
- Publisher
- The Company of Biologists
- Published
- 2019-07-01
- Volume
- 12
- Issue
- 7
- ISSN
- 1754-8403 (ISSN-L)
- 1754-8411
- OpenAlex
- W2964772567
- Cited by
- 377
- References
- 167
- FWCI
- 15.76
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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