Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age

Kiffin, Roberta, Kaushik, Susmita, Zeng, Mei, Bandyopadhyay, Urmi, Zhang, Cong, Massey, Ashish C., Martinez-Vicente, Marta, Cuervo, Ana Maria·2007·Journal of Cell Science

Cited by (213)

Items 101–200 of 213

  1. Modulating Chaperone-Mediated Autophagy and Its Clinical Applications in Cancer
    Virginie Hubert, Sebastian Weiss, Andrew Jackson Rees, Renate Kain · 2022 · Cells
  2. Sex-specific and cell-type-specific changes in chaperone-mediated autophagy across tissues during aging
    Rabia R. Khawaja, Adrián Martín‐Segura, Olaya Santiago‐Fernández, Rebecca Sereda, Kristen L. Lindenau, Mericka McCabe, Adrián Macho‐González, Maryam Jafari, Aurora Scrivo, Raquel Gómez‐Sintes et al. · 2025 · Nature Aging
  3. Role of endoplasmic reticulum stress and protein misfolding in disorders of the liver and pancreas
    Jan Lukáš, Jola Pospech, Christina Oppermann, Christina Hund, Katharina Iwanov, Supansa Pantoom, Janine Petters, Moritz J. Frech, Susanne Seemann, Franziska Gisela Thiel et al. · 2019 · Advances in Medical Sciences
  4. Molecular Chaperones and Proteolytic Machineries Regulate Protein Homeostasis in Aging Cells
    Boris A. Margulis, Цимоха Анна Сергеевна, Svetlana G. Zubova, Irina V. Guzhova · 2020 · Cells
  5. Autophagy and lipids: tightening the knot
    José Antonio Rodríguez‐Navarro, Ana María Cuervo · 2010 · Seminars in Immunopathology
  6. Impact of Chaperone-Mediated Autophagy in Brain Aging: Neurodegenerative Diseases and Glioblastoma
    Jaione Auzmendi-Iriarte, Ander Matheu · 2021 · Frontiers in Aging Neuroscience
  7. Connecting chaperone-mediated autophagy dysfunction to cellular senescence
    Daniel Moreno-Blas, Elisa Gorostieta-Salas, Susana Castro‐Obregón · 2017 · Ageing Research Reviews
  8. Chaperone-Mediated Autophagy in Neurodegenerative Diseases and Acute Neurological Insults in the Central Nervous System
    Haruo Kanno, Kyoichi Handa, Taishi Murakami, Toshimi Aizawa, Hiroshi Ozawa · 2022 · Cells
  9. Inhibition of class I PI3K enhances chaperone-mediated autophagy
    S. Joseph Endicott, Zachary Ziemba, Logan J. Beckmann, Dennis N. Boynton, Richard A. Miller · 2020 · The Journal of Cell Biology
  10. A pH probe inhibits senescence in mesenchymal stem cells
    Lihong Wang, Xianjing Han, Guojing Qu, Le Su, Bao‐Xiang Zhao, Jun‐Ying Miao · 2018 · Stem Cell Research & Therapy
  11. Morphological and biochemical studies on aging and autophagy
    Rita Rezzani, Alessandra Stacchiotti, Luigi Fabrizio Rodella · 2011 · Ageing Research Reviews
  12. Chaperone-mediated autophagy as a therapeutic target for Parkinson disease
    Philip Campbell, Huw R. Morris, Anthony H.V. Schapira · 2018 · Expert Opinion on Therapeutic Targets
  13. Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy
    S. Joseph Endicott, Dennis N. Boynton, Logan J. Beckmann, Richard A. Miller · 2020 · Autophagy
  14. Proteostasis Dysfunction in Aged Mammalian Cells. The Stressful Role of Inflammation
    D. Ruano · 2021 · Frontiers in Molecular Biosciences
  15. BECN1/Beclin 1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid β 42
    Jihoon Nah, Jong-Ok Pyo, Sunmin Jung, Seung-Min Yoo, Tae‐In Kam, Jae-Woong Chang, Jonghee Han, Seong Soo A. An, Takashi Onodera, Yong‐Keun Jung · 2013 · Autophagy
  16. Mitotic Dysfunction Associated with Aging Hallmarks
    Joana Catarina Macedo, Sara Vaz, Elsa Logarinho · 2017 · Advances in experimental medicine and biology
  17. Methods to Study Chaperone-Mediated Autophagy
    Esperanza Arias · 2016 · Methods in enzymology on CD-ROM/Methods in enzymology
  18. CSF lamp2 concentrations are decreased in female Parkinson’s disease patients with LRRK2 mutations
    Andrea C. Klaver, Mary P. Coffey, Jan Olav Aasly, David A. Loeffler · 2018 · Brain Research
  19. Calorie restriction and calorie-restriction mimetics activate chaperone-mediated autophagy
    Maryam Jafari, Adrián Macho‐González, Antonio Díaz, Kristen L. Lindenau, Olaya Santiago‐Fernández, Mei Zeng, Ashish C. Massey, Rafael de Cabo, Susmita Kaushik, Ana María Cuervo · 2024 · Proceedings of the National Academy of Sciences
  20. Lipids and Lysosomes
    Isabelle Hamer, Guillaume Van Beersel, Thierry Arnould, Michel Jadot · 2012 · Current Drug Metabolism
  21. Autophagy and lysosomal pathways in nervous system disorders
    Baris Bingol · 2018 · Molecular and Cellular Neuroscience
  22. Cell Autophagy in NASH and NASH-Related Hepatocellular Carcinoma
    Utibe‐Abasi S. Udoh, Pradeep Kumar Rajan, Yuto Nakafuku, Robert Finley, Juan Ramon Sanabria · 2022 · International Journal of Molecular Sciences
  23. Chaperone-mediated autophagy and disease: Implications for cancer and neurodegeneration
    Raquel Gómez‐Sintes, Esperanza Arias · 2021 · Molecular Aspects of Medicine
  24. The interplay between aging‐associated loss of protein homeostasis and extracellular vesicles in neurodegeneration
    Francesc Xavier Guix · 2019 · Journal of Neuroscience Research
  25. Defective chaperone-mediated autophagy is a hallmark of joint disease in patients with knee osteoarthritis
    Irene Lorenzo-Gómez, Uxía Nogueira-Recalde, Christian Garcia-Dominguez, Natividad Oreiro-Villar, Martin Lotz, J. Pinto-Tasende, Francisco Javier Blanco, Beatriz Caramés · 2023 · Osteoarthritis and Cartilage
  26. Cholesterol trafficking, lysosomal function, and atherosclerosis
    Alaa Skeyni, Alain Pradignac, Rachel L. Matz, Jérôme Terrand, Philippe Boucher · 2023 · American Journal of Physiology-Cell Physiology
  27. GSM-900 MHz at low dose temperature-dependently downregulates α-synuclein in cultured cerebral cells independently of chaperone-mediated-autophagy
    Faraj Terro, Amandine Magnaudeix, Marion Crochetet, Ludovic Martin, Sylvie Bourthoumieu, Cornelia M. Wilson, Catherine Yardin, Philippe Lévêque · 2011 · Toxicology
  28. Selective protein degradation through chaperone‑mediated autophagy: Implications for cellular homeostasis and disease (Review)
    Jiahui Huang, Jiazhen Wang · 2024 · Molecular Medicine Reports
  29. Restoration of LAMP2A expression in old mice leads to changes in the T cell compartment that support improved immune function
    Cara A. Reynolds, Sandra Pelka, Floralba Gjergjova, Inmaculada Tasset, Rabia R. Khawaja, Kristen L. Lindenau, Gregory J. Krause, Evripidis Gavathiotis, Ana María Cuervo, Fernando Macián · 2024 · Proceedings of the National Academy of Sciences
  30. Age-related decline of chaperone-mediated autophagy in skeletal muscle leads to progressive myopathy
    Olaya Santiago‐Fernández, Luisa Coletto, Inmaculada Tasset, Susmita Kaushik, Axel R. Concepcion, Rizwan Qaisar, Adrián Macho-González, Kristen L. Lindenau, Antonio Díaz, Rabia R. Khawaja et al. · 2025 · Nature Metabolism
  31. Targeting LAMP2 in human cerebrospinal fluid with a combination of immunopurification and high resolution parallel reaction monitoring mass spectrometry
    Simon Sjödin, Annika Öhrfelt, Gunnar Brinkmalm, Henrik Zetterberg, Kaj Blennow, Ann Brinkmalm · 2016 · Clinical Proteomics
  32. Mechanisms of l-Serine-Mediated Neuroprotection Include Selective Activation of Lysosomal Cathepsins B and L
    Rachael A. Dunlop, John M. Carney · 2020 · Neurotoxicity Research
  33. An insight into the concept of neuroinflammation and neurodegeneration in Alzheimer’s disease: targeting molecular approach Nrf2, NF-κB, and CREB
    Shaveta Bhardwaj, Amarjot Kaur Grewal, Shamsher Singh, Vaibhav Dhankar, Anu Jindal · 2024 · Inflammopharmacology
  34. Keeping synapses in shape: degradation pathways in the healthy and aging brain
    Marijn Kuijpers · 2022 · Neuronal Signaling
  35. β-Secretase 1’s Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice
    Diego Piedrahita, John Fredy Castro-Álvarez, Ryan L. Boudreau, Andrés Villegas‐Lanau, Kenneth S. Kosik, Juan Carlos Gallego-Gómez, Gloria Patricia Cardona‐Gómez · 2016 · Frontiers in Cellular Neuroscience
  36. Chaperone-Mediated Autophagy in the Kidney: The Road More Traveled
    Harold A. Franch · 2013 · Seminars in Nephrology
  37. Remodeling of Proteostasis Upon Transition to Adulthood is Linked to Reproduction Onset
    Nadav Shai, Netta Shemesh, Anat Ben‐Zvi · 2014 · Current Genomics
  38. Chaperone-mediated autophagy protects against hyperglycemic stress
    Emilio J. Vélez, Simon Schnebert, Maxime Goguet, Sara Balbuena-Pecino, Karine Dias, Linda Beauclair, Stéphanie Fontagné-Dicharry, Vincent Véron, Alexandra Depincé, Florian Beaumatin et al. · 2023 · Autophagy
  39. Chronic Infections: A Possible Scenario for Autophagy and Senescence Cross-Talk
    Milton Osmar Aguilera, Laura Ruth Delgui, Patricia Silvia Romano, María Isabel Colombo · 2018 · Cells
  40. New Insights into the Mechanisms of Chaperon-Mediated Autophagy and Implications for Kidney Diseases
    Zhen Yuan, Shuyuan Wang, Xiaoyue Tan, Dekun Wang · 2022 · Cells
  41. Chaperone-mediated autophagy and neurodegeneration: connections, mechanisms, and therapeutic implications
    Xiaolei Liu, Sihua Huang, Xingqin Wang, Beisha Tang, Wenming Li, Zixu Mao · 2015 · Neuroscience Bulletin
  42. Chaperone-mediated autophagy dysregulation during aging impairs hepatic fatty acid oxidation via accumulation of NCoR1
    You‐Jin Choi, Sung Ho Yun, Jihyeon Yu, Yewon Mun, Wonseok Lee, Cheon Jun Park, Byung Woo Han, Byung‐Hoon Lee · 2023 · Molecular Metabolism
  43. Targeting chaperone-mediated autophagy in neurodegenerative diseases: mechanisms and therapeutic potential
    Jin Wu, Wan Xu, Ying Su, Guanghui Wang, Jingjing Ma · 2024 · Acta Pharmacologica Sinica
  44. Chaperone-mediated autophagy: dedicated saviour and unfortunate victim in the neurodegeneration arena
    Jaime Laurel Schneider, Ana María Cuervo · 2013 · Biochemical Society Transactions
  45. Ambient temperature reduction extends lifespan via activating cellular degradation activity in an annual fish (Nothobranchius rachovii)
    Cheng‐Yen Lu, Chin‐Yuan Hsu · 2015 · AGE
  46. The Complex Role of Chaperone-Mediated Autophagy in Cancer Diseases
    Jing Liu, Lijuan Wang, Hua He, Yueying Liu, Yiqun Jiang, Jinfeng Yang · 2023 · Biomedicines
  47. Proteostasis in T cell aging
    A. E. Gressler, Hou-Fu Leng, Heidi Zinecker, A. Simon · 2023 · Seminars in Immunology
  48. The Antioxidative Role of Chaperone-Mediated Autophagy as a Downstream Regulator of Oxidative Stress in Human Diseases
    Shuangshuang Le, Xin Fu, Maogui Pang, Yao Zhou, Guoqing Yin, Jie Zhang, Daiming Fan · 2022 · Technology in Cancer Research & Treatment
  49. Dualistic role of autophagy in cancer progression
    Kacper Turek, Michał Jarocki, Julita Kulbacka, Jolanta Saczko · 2021 · Advances in Clinical and Experimental Medicine
  50. Regulation of autophagy by amino acid availability in S. cerevisiae and mammalian cells
    Hagai Abeliovich · 2014 · Amino Acids
  51. Chaperone-mediated autophagy as a modulator of aging and longevity
    S. Joseph Endicott · 2024 · Frontiers in Aging
  52. Downregulation of Lysosome-Associated Membrane Protein-2A Contributes to the Pathogenesis of COPD
    Yun-Jeong Jeong, Kyoung‐Hee Lee, Jisu Woo, Ji Yeon Kim, Chang‐Hoon Lee, Chul‐Gyu Yoo · 2023 · International Journal of COPD
  53. Selective autophagy: a therapeutic target for healthy aging?
    D. M. Manastireanu, N. Salazar, Eloy Bejarano, J. L. Nieto-Torres · 2024 · Aging Advances
  54. Changes in Lysosomes and Their Autophagic Function in Aging: The Comparative Biology of Lysosomal Function
    Samantha J. Orenstein, Ana María Cuervo · 2009 · Springer eBooks
  55. Defective chaperone-mediated autophagy in the retinal pigment epithelium of age-related macular degeneration patients
    Juan Ignacio Jiménez‐Loygorri, Peng Shang, Ibrahim Bayramoglu, Raquel Gómez‐Sintes, Adrián Martín‐Segura, Helena Ambrosino, Johnson Hoang, Antonio Díaz, Zhaohui Geng, Evripidis Gavathiotis et al. · 2025 · EMBO Molecular Medicine
  56. Autophagy as an Anti-senescent in Aging Neurocytes
    Basheer Abdullah Marzoog · 2023 · Current Molecular Medicine
  57. Chaperone-mediated autophagy in fish: A key function amid a changing environment
    Simon Schnebert, Emilio J. Vélez, Maxime Goguet, Karine Dias, Vincent Véron, Isabel García-Pérez, Lisa M. Radler, Emilie Cardona, Stéphanie Fontagné-Dicharry, Pierre Van Delft et al. · 2024 · Autophagy Reports
  58. HSF1 Regulation in Aging and Its Role in Longevity
    Netta Shemesh, Anat Ben‐Zvi · 2016 · Springer eBooks
  59. LAMP2A, and other chaperone-mediated autophagy related proteins, do not decline with age in genetically heterogeneous UM-HET3 mice
    Katherine K. Zhang, Peichuan Zhang, Anagha Kodur, İlkim Ertürk, Calvin M. Burns, Cynthia J. Kenyon, Richard A. Miller, S. Joseph Endicott · 2023 · Aging
  60. The Treatment of Parkinson’s Disease with Sodium Oxybate
    Mortimer Mamelak · 2022 · Current Molecular Pharmacology
  61. Acetylation of Hsc70 at K512 inhibits goat ovarian granulosa cell senescence by restoring chaperone-mediated autophagy
    Yawen Li, Yukun Wang, Hui Yao, Ziyuan Li, Lei Wang, Shuaifei Song, Jiayue Li, Yaru Li, Mingzhi Yang, Ke Zhang et al. · 2025 · International Journal of Biological Macromolecules
  62. Human cardiac ischemia‐reperfusion injury: Blunted stress response with age
    Ashley Nicole Oliveira, Bobby Yanagawa, Adrian Quan, Subodh Verma, David Albert Hood · 2021 · Journal of Cardiac Surgery
  63. Antioxidants and Polyphenols Mediate Mitochondrial Mediated Muscle Death Signaling in Sarcopenia
    Stephen E. Alway · 2018 · Elsevier eBooks
  64. The Lysosome in Aging‐Related Neurodegenerative Diseases
    Ralph A. Nixon · 2016 · Wiley eBooks
  65. Lysosomal membrane protein TMEM106B modulates hematopoietic stem and progenitor cell proliferation and differentiation by regulating LAMP2A stability
    Di Guo, Hongbo Xiong, Zhongcheng Yang, Rui Zhang, Pengcheng Shi, Yufeng Yao, Mugen Liu, Chengqi Xu, Qing Kenneth Wang · 2024 · The FASEB Journal
  66. Loss of chaperone‐mediated autophagy does not alter age‐related bone loss in male mice
    James A. Hendrixson, Alicen James, Nisreen S. Akel, Dominique J. Laster, Julie A. Crawford, Stuart B. Berryhill, Melda Onal · 2024 · FASEB BioAdvances
  67. The autophagy activator Spermidine ameliorates Alzheimer’s disease pathology and neuroinflammation in mice
    Kiara Freitag, Nele Sterczyk, Julia Schulz, Judith Houtman, Lara Fleck, Stephan J. Sigrist, Frank L. Heppner, Marina Jendrach · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  68. Lipophagy: exploring its association with male reproductive system disorders and investigating potential mechanisms
    Wanyi Chen, Jin Chen, Ziqiong Cheng, Weilun Chen, Huiping Zhang · 2025 · Archives of Physiology and Biochemistry
  69. Targeting chaperone-mediated autophagy to regulate osteoclast activity as a therapeutic strategy for osteoporosis
    Yunhui Zhang, Quanfeng Li, Xiaoshuai Peng, Pengfei Ji, Yibin Zhang, Jiahao Jin, Zihao Yuan, Jianan Jiang, Guangqi Tian, Mingxi Cai et al. · 2025 · Materials Today Bio
  70. Neurodegenerative Diseases and the Aging Brain
    Stephen K. Godin, Jinsoo Seo, Li‐Huei Tsai · 2018 · Elsevier eBooks
  71. Autophagy, the “Master” Regulator of Cellular Quality Control: What Happens when Autophagy Fails?
    Ana Raquel, R Almeida Catarina, Sandra Morais · 2013 · InTech eBooks
  72. Chaperone‐Mediated Autophagy: A Critical Regulator of Neuroinflammation and Neurodegeneration
    Yingying Han, Xinyue Huang, Ying Su, Jingjing Ma, Jin Wu · 2025 · Advanced Biology
  73. Protein clearance mechanisms and their demise in age-related neurodegenerative diseases
    Isabel Sáez, David Vı́lchez · 2015 · AIMS molecular science
  74. Expression of Autophagy Markers LC3B, LAMP2A, and GRP78 in the Human Kidney during Embryonic, Early Fetal, and Postnatal Development and Their Significance in Diabetic Kidney Disease
    Ivan Brdar, Anita Racetin, I Jelicić, Katarina Vukojević, Ljiljana Vučković, Dragan Ljutić, Mirna Saraga‐Babić, Natalija Filipović · 2024 · International Journal of Molecular Sciences
  75. Autophagy and Huntington's disease
    Katherine R. Croce, Hilary Grosso Jasutkar, Ai Yamamoto · 2024 · Elsevier eBooks
  76. Exploring the Potential of Herbal Compounds as Autophagy Modulators in Alzheimer's Disease: A Comprehensive Review
    Ekta Yadav, Ashok Kumar Mandal, Ajay Kumar Sah, Sandesh Poudel, Prateek Pathak, Habibullah Khalilullah, Mariusz Jaremko, Abdul-Hamid M. Emwas, Pankajkumar S. Yadav, Amita Verma · 2024 · CNS & Neurological Disorders - Drug Targets
  77. Chaperone-Mediated Autophagy in Health and Disease
    Susmita Kaushik · 2025 · Learning materials in biosciences
  78. Role of Chaperone-Mediated Autophagy in Ageing and Neurodegeneration
    João Vasco Ferreira, Paulo Pereira, Henrique Girão · 2015 · Current topics in neurotoxicity
  79. Apoptosis in Neurodegenerative Diseases
    Qiuli Liang, Jianhua Zhang · 2009 · Humana Press eBooks
  80. MicroRNAs Regulating Autophagy in Neurodegeneration
    Qingxuan Lai, Nikolai Kovzel, Ruslan Konovalov, Ilya A. Vinnikov · 2021 · Advances in experimental medicine and biology
  81. The interplay between Lewy body-like alpha-synuclein aggregates and protein degradation pathways in a cell-based model of Parkinson's disease
    Selcuk A. Tanik · 2013 · Scholarly Commons (University of Pennsylvania)
  82. Protein Degradation and the Lysosomal System
    Susmita Kaushik, Ana María Cuervo · 2020 · Wiley eBooks
  83. The pleiotropic impact of chaperone-mediated autophagy on skeletal muscle integrity
    Dimitra Dialynaki, Daniel J. Klionsky · 2026 · Autophagy
  84. Protein Degradation and the Lysosomal System
    Susmita Kaushik, Ana María Cuervo · 2009 · Wiley eBooks
  85. Regional lysosomal malfunction underlies the selectivity of alpha-synuclein neurodegeneration
    Kristen A. Malkus · 2011 · Scholarly Commons (University of Pennsylvania)
  86. Effects of Aggregated Alpha-Synuclein on Cultured Neuronal Cells
    David W. Freeman · 2015 · Loyola eCommons (Loyola University of Chicago)
  87. Meeting Report: Seventh Annaberg EMBO Workshop ‘Membrane Traffic in the Secretory Pathway’, Goldegg, Austria, 9–14 January 2007
    Joëlle Morvan, Sara Salinas, Veronika E. Neubrand · 2007 · Traffic
  88. Protein Homeostasis and Aging
    Susmita Kaushik, Ana María Cuervo · 2010 · Elsevier eBooks
  89. CHAPERONE-MEDIATED AUTOPHAGY (CMA) IN NEURONS
    Maria Xilouri, Hsiao-Yu Peng, Leonidas Stefanis · 2012 · WORLD SCIENTIFIC eBooks
  90. Autophagy and Aging
    Jaime Laurel Schneider, Ana María Cuervo · 2012 · Oxidative stress and disease
  91. Bases metabólicas da rabdomiólise e atrofia muscular
    Rodrigo Minoru Manda, Roberto Carlos Burini · 2010 · Revista Brasileira de Fisiologia do Exercício
  92. Lysosomal interplay between ubiquitination and phosphorylation regulates chaperone-mediated autophagy
    Moumita Rakshit · 2017
  93. Evaluation of the Endo-Lysosomal System and the Ubiquitin-Proteasome System in Neurodegenerative Diseases
    Simon Sjödin · 2018 · Gothenburg University Publications Electronic Archive (Gothenburg University)
  94. Autophagy and T Cell Aging
    Fernando Macián · 2018 · Springer eBooks
  95. Chaperone-Mediated Autophagy
    Esther S.P. Wong · 2018 · Elsevier eBooks
  96. Mitochondrial dysfunction and autophagy in neurodegeneration
    Rohan V. Gupta, Rashmi K. Ambasta, Pravir Kumar · 2021 · Elsevier eBooks
  97. Chaperone-mediated autophagy—mechanisms and disease role
    Amelina Albornoz, Álvaro Sequeida, Christian Rodríguez, Mauricio Budini · 2021 · Elsevier eBooks
  98. Autophagy and T Cell Aging
    Fernando Macián · 2019 · Springer eBooks
  99. Current World Literature
    2008 · Current Opinion in Clinical Nutrition & Metabolic Care
  100. The effect of intra- and extracellular challenges on cellular responses in atherosclerosis
    Kim van Kuijk · 2021