The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Targeted alterations in iron homeostasis underlie plant defense responses
Abstract
Iron (Fe) is a ubiquitous redox-active element essential for most life. The formation of localized cell wall appositions, the oxidative burst and the production of pathogenesis-related proteins are hallmarks of plant defense responses. Here, we report that iron is a central mediator linking these three phenomena. We show that in response to pathogen attack, reactive Fe3+, but not Fe2+, is deposited at cell wall appositions where it accumulates and mediates the oxidative burst. We provide evidence that the bulk secretion of Fe3+ provoked by pathogen attack leads to intracellular iron depletion, and that H2O2 itself induces ATP-dependent intracellular iron efflux. Finally, we demonstrate that this intracellular iron depletion promotes the transcription of pathogenesis-related genes in concert with H2O2. This work identifies iron as an underlying factor associated with the oxidative burst and regulating cereal defenses, and establishes links between disease-related iron homeostasis in plants and animals.
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Hentze, M. W., Muckenthaler, M. U., & Andrews, N. C. (2004) · Cell · doi:10.1016/s0092-8674(04)00343-5 · Cited by 1,736
Regulation of ferritin genes and protein
Torti, F. M., & Torti, S. V. (2002) · Blood · doi:10.1182/blood.v99.10.3505 · Cited by 1,173
Schaible, U. E., & Kaufmann, S. H. E. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro1046 · Cited by 945
Schrettl, M., Bignell, E., Kragl, C., Joechl, C., Rogers, T., Arst, H. N., Haynes, K., & Haas, H. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041242 · Cited by 493
Cited by
Loss of Function of a Proline-Containing Protein Confers Durable Disease Resistance in Rice
Fukuoka, S., Saka, N., Koga, H., Ono, K., Shimizu, T., Ebana, K., Hayashi, N., Takahashi, A., Hirochika, H., Okuno, K., et al. (2009) · Science · doi:10.1126/science.1175550 · Cited by 678
Towards establishing broad-spectrum disease resistance in plants: silicon leads the way
Van Bockhaven, J., De Vleesschauwer, D., & Höfte, M. (2013) · Journal of Experimental Botany · doi:10.1093/jxb/ers329 · Cited by 371
A soil bacterium regulates plant acquisition of iron via deficiency‐inducible mechanisms
Zhang, H., Sun, Y., Xie, X., Kim, M., Dowd, S. E., & Paré, P. W. (2009) · The Plant Journal · doi:10.1111/j.1365-313x.2009.03803.x · Cited by 369
Iron-Dependent Callose Deposition Adjusts Root Meristem Maintenance to Phosphate Availability
Müller, J., Toev, T., Heisters, M., Teller, J., Moore, K. L., Hause, G., Dinesh, D. C., Bürstenbinder, K., & Abel, S. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.02.007 · Cited by 344
Verbon, E. H., Trapet, P. L., Stringlis, I. A., Kruijs, S., Bakker, P. A. H. M., & Pieterse, C. M. J. (2017) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-080516-035537 · Cited by 241
Metadata
- Authors
- Liu, G., Greenshields, D. L., Sammynaiken, R., Hirji, R. N., Selvaraj, G., & Wei, Y.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2007-02-15
- Volume
- 120
- Issue
- 4
- Pages
- 596-605
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2166715567
- Cited by
- 176
- References
- 4
- FWCI
- 11.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, G., Greenshields, D. L., Sammynaiken, R., Hirji, R. N., Selvaraj, G., & Wei, Y. (2007). Targeted alterations in iron homeostasis underlie plant defense responses. Journal of Cell Science. https://doi.org/10.1242/jcs.001362
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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