The DOI matches its Crossref record; 117 of the 119 references it cites were found in a registry or an index.
Potential role of MCP-1 in endothelial cell tight junction `opening': signaling via Rho and Rho kinase
Abstract
The expression of the monocyte chemoattractant protein-1 (MCP-1) receptor CCR2 by brain endothelial cells suggests that MCP-1 may have other functions than purely driving leukocyte migration into brain parenchyma during inflammation. This study examines one of these potential novel roles of MCP-1 regulation of endothelial permeability using primary cultures of mouse brain endothelial cells. MCP-1 induces reorganization of actin cytoskeleton (stress fiber formation) and redistribution of tight junction proteins, ZO-1, ZO-2 occludin and claudin-5, from the Triton X-100-soluble to the Triton X-100-insoluble fractions. These morphological changes are associated with a decrease in transendothelial electrical membrane resistance and an increase in [14C]inulin permeability. MCP-1 did not induce these events in brain endothelial cells prepared from mice genotype CCR2-/-. The Rho kinase inhibitor Y27632 and inhibition of Rho (C3 exoenzyme, and dominant negative mutant of Rho, RhoT19N) prevented MCP-1-induced stress fiber assembly, reorganization of tight junction proteins and alterations in endothelial permeability. In all, this suggests that a small GTPase Rho and Rho kinase have a pivotal role in MCP-1-induced junction disarrangement. These data are the first to strongly suggest that MCP-1, via CCR2 present on brain endothelial cells, contributes to increased brain endothelial permeability.
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Etienne-Manneville, S., & Hall, A. (2002) · Nature · doi:10.1038/nature01148 · Cited by 4,965
Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)
Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., et al. (1996) · Science · doi:10.1126/science.273.5272.245 · Cited by 2,889
Rollins, B. J. (1997) · Blood · doi:10.1182/blood.v90.3.909.909_909_928 · Cited by 2,126
Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)
Amano, M., Ito, M., Kimura, K., Fukata, Y., Chihara, K., Nakano, T., Matsuura, Y., & Kaibuchi, K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.34.20246 · Cited by 2,009
Boring, L., Gosling, J., Cleary, M., & Charo, I. F. (1998) · Nature · doi:10.1038/29788 · Cited by 1,965
Martín-Padura, I., Lostaglio, S., Schneemann, M., Williams, L., Romano, M., Fruscella, P., Panzeri, C., Stoppacciaro, A., Ruco, L., Villa, A., et al. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.1.117 · Cited by 1,387
The Molecular Biology of Leukocyte Chemoattractant Receptors
Murphy, P. M. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.003113 · Cited by 1,197
THE CELL BIOLOGY OF THE BLOOD-BRAIN BARRIER
Rubin, L. L., & Staddon, J. M. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.11 · Cited by 1,017
Signalling to and from tight junctions
Matter, K., & Balda, M. (2003) · Nature reviews. Molecular cell biology · doi:10.1038/nrm1055 · Cited by 926
Rosenberg, G. A., Estrada, E. Y., & Dencoff, J. E. (1998) · Stroke · doi:10.1161/01.str.29.10.2189 · Cited by 861
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Research works printed but not linked: 2
- Rollins, B. J. (1997). Chemokines.Blood90, 909-928. · DOI
- Wolburg, H. and Risau, W. (1995). Formation of the blood-brain barrier. In Neuroglia (ed. H. Kettenmann and B. R. Ransom), pp. 763-776. Oxford: Oxford University Press.
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Items 301–383 of 383
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Ravisankar, V., Nakka, V. P., Simhadri, P. K., Baruah, U. K., & Babu, P. P. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.01.020 · Cited by 10
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Minami, M. (2011) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.131.539 · Cited by 10
Vatter, P., Schuhholz, J., Koenig, C., Pfreimer, M., & Moepps, B. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.2ma0815-386r · Cited by 10
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Mouse MCP1 C‐terminus inhibits human MCP1‐induced chemotaxis and BBB compromise
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Minami, M., & Satoh, M. (2005) · NeuroMolecular Medicine · doi:10.1385/nmm:7:1-2:149 · Cited by 9
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Then, C., Bergler, T., Jeblick, R., Jung, B., Banas, B., & Krämer, B. K. (2011) · Nephron Physiology · doi:10.1159/000327567 · Cited by 6
Dechkum, N., Hananantachai, H., Patarapotikul, J., Ohashi, J., Krudsood, S., Looareesuwan, S., & Tokunaga, K. (2006) · Japanese Journal of Infectious Diseases · doi:10.7883/yoken.jjid.2006.239 · Cited by 6
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Park, J.-E., Freeman, B. H., Park, H., Kim, S., Bafor, A. E., Myint, O., Gao, S., Xu, Z., Körbelin, J., Aronowski, J. A., et al. (2026) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x261421424 · Cited by 3
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Butz, S., & Vestweber, D. (2007) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-7975-9_11 · Cited by 3
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Marshall, S. A. (2013) · UKnowledge (University of Kentucky) · Cited by 1
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Wang, Y., Li, F., Wang, S., Meng, J., Zhang, X., & Wei, W. (2024) · Particuology · doi:10.1016/j.partic.2024.03.005 · Cited by 2
Alijagić, A., Seilitz, F., Bredberg, A., Hakonen, A., Larsson, M., Selin, E., Sjöberg, V., Kotlyar, O., Scherbak, N. N., Repsilber, D., et al. (2025) · Environmental Research · doi:10.1016/j.envres.2025.120929 · Cited by 1
Mathur, A., Kamat, A., Philp, B., Tabb, J., Thomas, R., Mahajan, P., Caldwell, J. T., & Kamat, D. (2016) · International Journal of Child Health and Nutrition · doi:10.6000/1929-4247.2016.05.02.3 · Cited by 1
Broekaart, D. W. M., Korotkov, A., Gorter, J. A., & van Vliet, E. A. (2021) · Progress in inflammation research · doi:10.1007/978-3-030-67403-8_4 · Cited by 1
Özkan, A., Stolley, D. L., Cressman, E. N. K., McMillin, M., Yankeelov, T. E., & Rylander, M. N. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.04.490682 · Cited by 1
Kaur, G., Pant, P., Bhagat, R., & Seth, P. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.09.527854 · Cited by 1
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Neck, S. D., Penrice-Randal, R., Neves, L. X., Seehusen, F., Sharma, P., Helminger, B., Kirby, A., Mega, D., Erdmann, M., Zanella, M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.07.637145 · Cited by 1
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Chen, Y., Goodenough, D. A., & Lu, Q. (2007) · Springer eBooks · doi:10.1007/0-387-36673-3_2
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Lum, H. (2005) · Advances in molecular and cell biology · doi:10.1016/s1569-2558(05)35003-x
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Barr, T. L. (2009) · D-Scholarship@Pitt (University of Pittsburgh)
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Wang, J., Xu, J., Zhao, X., Xie, W., Wang, H., & Kong, H. (2017) · Preprints.org · doi:10.20944/preprints201703.0225.v1
Beal, R. W. (2018) · Queen Mary Research Online (Queen Mary University of London)
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Yang, I.-H. (2019) · UCL Discovery (University College London)
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Berghoff, S. A. (2020) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-8239
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高, 春. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.133689
Tang, Y., Yang, H.-C., Yin, Y., Wang, M., He, B., Ye, L., Li, R., Yu, C.-J., Di, R., Xu, Q., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-3831426/v1
Yang, R., Huang, K., Zhang, H.-P., Li, L., Tan, C., Chen, H., Jin, M., & Wang, X. (2022) · Figshare · doi:10.6084/m9.figshare.20252834
Yang, R., Huang, K., Zhang, H.-P., Li, L., Tan, C., Chen, H., Jin, M., & Wang, X. (2022) · Figshare · doi:10.6084/m9.figshare.20252837
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Zierfuss, B., Charabati, M., MacVicar, B. A., Zandee, S., & Prat, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-823848-6.00011-7
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Manjila, S. V., Ranjini, N. J., Ravindran, P., Mariappan, V., Pillai, A. B., Prabhune, A., Lalwani, C. S., Menon, S. S., Karadan, U., & Kirsch, C. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13833-1.00006-5
An, Y.-Z., Cho, E., Ling, J., & Zhang, X. (2020) · Figshare · doi:10.6084/m9.figshare.13082900
An, Y.-Z., Cho, E., Ling, J., & Zhang, X. (2020) · Figshare · doi:10.6084/m9.figshare.13082903
An, Y.-Z., Cho, E., Ling, J., & Zhang, X. (2020) · Figshare · doi:10.6084/m9.figshare.13082909
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Feige, L. (2021) · theses.fr (ABES) · doi:10.70675/c423b214z3cc0z4976za6fazc5bc61c40274
Cao, Y., Wu, X., Yao, J., Lou, H., Sun, Y., Jiang, J., Song, Y., Meng, X., Du, C., Da, D., et al. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1909220
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Pedreáñez, A. B., Carrero, Y. N., Hernández–Fonseca, H., Vargas, R., Fonseca, J. P. H., & Mosquera-Sulbarán, J. (2026) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/14703203261485159
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The importance of the Hedgehog signaling pathway at the level of the blood-brain barrier
Dodelet-Devillers, A. (2009) · doi:10.71781/29601
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Willing, A. E., Chen, N., Pennypacker, K. R., & Sanberg, P. R. (2007) · Humana Press eBooks · doi:10.1007/978-1-60327-057-1_3
(2006) · PubMed · Cited by 158
Metadata
- Authors
- Stamatovic, S. M., Keep, R. F., Kunkel, S. L., & Andjelkovic, A. V.
- Affiliations
- University of Michigan (US)
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2003-11-15
- Volume
- 116
- Issue
- 22
- Pages
- 4615-4628
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W1968099474
- Cited by
- 381
- References
- 119
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 14 · 2023: 20 · 2022: 15 · 2021: 19 · 2020: 20 · 2019: 21 · 2018: 19 · 2017: 17 · 2016: 19 · 2015: 20 · 2014: 16 · 2013: 20 · 2012: 21
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cell Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Keywords
- MCP-1, CCR2, brain endothelial cells, endothelial permeability, tight junctions, Rho kinase, Rho GTPases, actin cytoskeleton remodeling, stress fibers, ZO-1, occludin, claudin-5, transendothelial electrical resistance, leukocyte migration
- MeSH terms
- Acute-Phase Proteins, Animals, Brain, Cells, Cultured, Inulin, Membrane Proteins, Microscopy, Fluorescence, Mutation, Permeability, Electric Impedance, Protein Serine-Threonine Kinases, Octoxynol, Mice, Knockout, Chemokine CCL2, Tight Junctions, Receptors, Chemokine, Oligonucleotide Array Sequence Analysis, Stress Fibers, Endothelial Cells, Intracellular Signaling Peptides and Proteins, Mice, Receptors, CCR2, rho-Associated Kinases, Claudin-5, Occludin, Zonula Occludens-2 Protein
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