Integrins and cell-fate determination
Open accessAbstract
All cellular processes are determined by adhesive interactions between cells and their local microenvironment. Integrins, which constitute one class of cell-adhesion receptor, are multifunctional proteins that link cells to the extracellular matrix and organise integrin adhesion complexes at the cell periphery. Integrin-based adhesions provide anchor points for assembling and organising the cytoskeleton and cell shape, and for orchestrating migration. Integrins also control the fate and function of cells by influencing their proliferation, apoptosis and differentiation. Moreover, new literature demonstrates that integrins control the cell-division axis at mitosis. This extends the influence of integrins over cell-fate decisions, as daughter cells are frequently located in new microenvironments that determine their behaviour following cell division. In this Commentary, I describe how integrins influence cell-fate determination, placing particular emphasis on their role in influencing the direction of cell division and the orientation of the mitotic spindle.
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Cell fate is intimately tied to interactions between cell surface integrins and biochemical cues in the ECM.
“In addition to judicious selection of cell type, cell fate is intimately tied to interactions between cell surface integrins and biochemical cues in the ECM92.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [92]
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References 70 · Cited by 220
Research works printed but not linked: 1
- Streuli, C. H. and Akhtar, N. (2009). Signal cooperation between integrins and other receptor systems. Biochem. J. (in press).
- Authors
- Streuli, C. H.
- Affiliations
- Wellcome Centre for Cell-Matrix Research (GB)
- Corresponding author
- Streuli, Charles H.
- ORCID
- Streuli, Charles H.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2009-01-15
- Volume
- 122
- Issue
- 2
- Pages
- 171-177
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- PMC
- PMC2714415
- OpenAlex
- W2002982362
- Cited by
- 220
- References
- 70
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 9 · 2023: 4 · 2022: 5 · 2021: 7 · 2020: 9 · 2019: 13 · 2018: 10 · 2017: 12 · 2016: 17 · 2015: 16 · 2014: 10 · 2013: 20 · 2012: 13
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Cell Science (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion, other-oa)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- integrins, cell fate determination, cell adhesion, extracellular matrix, cell division orientation, mitotic spindle orientation, cell migration, cytoskeleton, cell shape, cell differentiation, apoptosis, cell proliferation
- MeSH terms
- Animals, Cell Adhesion, Cell Differentiation, Cell Division, Cytoskeletal Proteins, Humans, Spindle Apparatus, Integrins, Cell Polarity, Apoptosis, Receptors, Growth Factor, Cell Proliferation
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