Cited by 92Microtubule and mitosis dynamicsGenomics and Chromatin DynamicsChromosomal and Genetic Variations

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The Drosophila ncd microtubule motor protein is spindle-associated in meiotic and mitotic cells

Hatsumi, Machiko, Endow, Sharyn A.·1992·Journal of Cell Science

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Abstract

The nonclaret disjunctional (ncd) protein is required for normal chromosome distribution in oocytes and early embryos. Mutants of ncd cause frequent nondisjunction and loss of chromosomes, suggesting a role for the protein in spindle function or chromosome movement in meiosis and early mitosis. The ncd protein contains a region of predicted sequence similarity to the microtubule motor protein, kinesin. In vitro motility assays have demonstrated that ncd is a motor that unexpectedly moves toward the minus ends of microtubules, opposite to the direction of kinesin movement. Using antibodies directed against nonconserved regions of the protein, we have localized the ncd motor protein to the meiotic and early mitotic spindle, and to spindles in a mitotically dividing cultured cell line. Its presence in the spindle of meiotic and mitotic cells implies a role for the protein as a spindle motor. The motor may play an essential role in establishing spindle bipolarity in meiosis.

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Authors: Hatsumi, M., & Endow, S. A.
Affiliations: Duke Medical Center (US)
ORCID: Endow, Sharyn A.
Venue: Journal of Cell Science
Publisher: The Company of Biologists
Published: 1992-12-01
Volume: 103
Issue: 4
Pages: 1013-1020
ISSN: 0021-9533 (ISSN-L)
1477-9137
DOI: 10.1242/jcs.103.4.1013
OpenAlex: W2106258850
Cited by: 92
References: 28
Citations by year: 2026: 1 · 2024: 1 · 2022: 1 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 1 · 2012: 1
FWCI: 2.05
Type: journal article
Language: en
Open access: closed
Licence: www.biologists.com/user-licence-1-1/ (vor)
Locations: Journal of Cell Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (R01GM046225)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Keywords: microtubule motor proteins, kinesin, meiosis, mitosis, nondisjunction, chromosome segregation, spindle bipolarity, oocytes, early embryonic development, minus-end-directed motility
MeSH terms: Amino Acid Sequence, Animals, Cells, Cultured, Drosophila melanogaster, Embryo, Nonmammalian, Fluorescent Antibody Technique, Meiosis, Microtubule Proteins, Microtubules, Mitosis, Spindle Apparatus, Molecular Sequence Data, Oocytes, Peptide Fragments, Rabbits, Kinesins, Drosophila Proteins

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The Drosophila ncd microtubule motor protein is spindle-associated in meiotic and mitotic cells

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