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Impaired mechanical stability, migration and contractile capacity in vimentin deficient fibroblasts
Abstract
Loss of a vimentin network due to gene disruption created viable mice that did not differ overtly from wild-type littermates. Here, primary fibroblasts derived from vimentin-deficient (-/-) and wild-type (+/+) mouse embryos were cultured, and biological functions were studied in in vitro systems resembling stress situations. Stiffness of -/fibroblasts was reduced by 40% in comparison to wild-type cells. Vimentin-deficient cells also displayed reduced mechanical stability, motility and directional migration towards different chemo-attractive stimuli. Reorganization of collagen fibrils and contraction of collagen lattices were severely impaired. The spatial organization of focal contact proteins, as well as actin microfilament organization was disturbed. Thus, absence of a vimentin filament network does not impair basic cellular functions needed for growth in culture, but cells are mechanically less stable, and we propose that therefore they are impaired in all functions depending upon mechanical stability.
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Citations
Cited by
Cellular mechanotransduction: putting all the pieces together again
Ingber, D. E. (2006) · The FASEB Journal · doi:10.1096/fj.05-5424rev · Cited by 1,627
Self-citationMiddeldorp, J., & Hol, E. M. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.005 · Cited by 1,080
Novel functions of vimentin in cell adhesion, migration, and signaling
Ivaska, J., Pallari, H.-M., Nevo, J., & Eriksson, J. E. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.03.040 · Cited by 785
Ingber, D. E. (2002) · Circulation Research · doi:10.1161/01.res.0000039537.73816.e5 · Cited by 621
Self-citationVimentin is secreted by activated macrophages
Mor-Vaknin, N., Punturieri, A., Sitwala, K., & Markovitz, D. M. (2003) · Nature Cell Biology · doi:10.1038/ncb898 · Cited by 522
Metadata
- Authors
- Eckes, B., Dogic, D., Colucci-Guyon, E., Wang, N., Maniotis, A., Ingber, D., Merckling, A., Langa, F., Aumailley, M., Delouvée, A., Koteliansky, V., Babinet, C., & Krieg, T.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 1998-07-01
- Volume
- 111
- Issue
- 13
- Pages
- 1897-1907
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2157162711
- Cited by
- 483
- References
- 0
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Eckes, B., Dogic, D., Colucci-Guyon, E., Wang, N., Maniotis, A., Ingber, D., Merckling, A., Langa, F., Aumailley, M., Delouvée, A., Koteliansky, V., Babinet, C., & Krieg, T. (1998). Impaired mechanical stability, migration and contractile capacity in vimentin deficient fibroblasts. Journal of Cell Science. https://doi.org/10.1242/jcs.111.13.1897
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