The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Mechanism and role of PDZ domains in signaling complex assembly
Abstract
PDZ domains are protein-protein recognition modules that play a central role in organizing diverse cell signaling assemblies. These domains specifically recognize short C-terminal peptide motifs, but can also recognize internal sequences that structurally mimic a terminus. PDZ domains can therefore be used in combination to bind an array of target proteins or to oligomerize into branched networks. Several PDZ-domain-containing proteins play an important role in the transport, localization and assembly of supramolecular signaling complexes. Examples of such PDZ-mediated assemblies exist in Drosophila photoreceptor cells and at mammalian synapses. The predominance of PDZ domains in metazoans indicates that this highly specialized scaffolding module probably evolved in response to the increased signaling needs of multicellular organisms.
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Cites
The sequence of the human genome
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Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains
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PSD-95 Involvement in Maturation of Excitatory Synapses
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Cited by
Watanabe, T., Wang, S., Noritake, J., Sato, K., Fukata, M., Takefuji, M., Nakagawa, M., Izumi, N., Akiyama, T., & Kaibuchi, K. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.10.017 · Cited by 480
A Specificity Map for the PDZ Domain Family
Tonikian, R., Zhang, Y., Sazinsky, S. L., Currell, B., Yeh, J.-H., Reva, B., Held, H. A., Appleton, B. A., Evangelista, M., Wu, Y., et al. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060239 · Cited by 476
Morin-Kensicki, E. M., Boone, B. N., Howell, M., Stonebraker, J. R., Teed, J., Alb, J. G., Magnuson, T. R., O'Neal, W., & Milgram, S. L. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.1.77-87.2006 · Cited by 429
NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex
Sans, N., Prybylowski, K., Petralia, R. S., Chang, K., Wang, Y.-X., Racca, C., Vicini, S., & Wenthold, R. J. (2003) · Nature Cell Biology · doi:10.1038/ncb990 · Cited by 327
Hay, D. L., Poyner, D. R., & Sexton, P. M. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.06.015 · Cited by 239
Metadata
- Authors
- Harris, B. Z., & Lim, W. A.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2001-09-15
- Volume
- 114
- Issue
- 18
- Pages
- 3219-3231
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2156999424
- Cited by
- 830
- References
- 5
- FWCI
- 17.37
- Type
- journal article
- Language
- en
- Open access
- closed
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