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The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Mechanism and role of PDZ domains in signaling complex assembly

Harris, Baruch Z., Lim, Wendell A.·2001·Journal of Cell Science

Abstract

PDZ domains are protein-protein recognition modules that play a central role in organizing diverse cell signaling assemblies. These domains specifically recognize short C-terminal peptide motifs, but can also recognize internal sequences that structurally mimic a terminus. PDZ domains can therefore be used in combination to bind an array of target proteins or to oligomerize into branched networks. Several PDZ-domain-containing proteins play an important role in the transport, localization and assembly of supramolecular signaling complexes. Examples of such PDZ-mediated assemblies exist in Drosophila photoreceptor cells and at mammalian synapses. The predominance of PDZ domains in metazoans indicates that this highly specialized scaffolding module probably evolved in response to the increased signaling needs of multicellular organisms.

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Crossref · 10.1242/jcs.114.18.3219

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Metadata

Authors
Harris, B. Z., & Lim, W. A.
Venue
Journal of Cell Science
Published
2001-09-15
Volume
114
Issue
18
Pages
3219-3231
ISSN
  • 0021-9533 (ISSN-L)
  • 1477-9137
OpenAlex
W2156999424
Cited by
830
References
5
FWCI
17.37
Type
journal article
Language
en
Open access
closed

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