The polarity protein Scribble positions DLC3 at adherens junctions to regulate Rho signaling

Hendrick, Janina; Franz-Wachtel, Mirita; Moeller, Yvonne; Schmid, Simone; Macek, Boris; Olayioye, Monilola A.

doi:10.1242/jcs.190074

The polarity protein Scribble positions DLC3 at adherens junctions to regulate Rho signaling

The spatial regulation of cellular Rho signaling by GAP proteins is still poorly understood. By performing mass spectrometry, we here identify the polarity protein Scribble as a scaffold for the RhoGAP protein DLC3 (also known as StarD8) at cell–cell adhesions. This mutually dependent interaction…