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The use of cell division cycle mutants to investigate the control of microtubule distribution in the fission yeast Schizosaccharomyces pombe
Abstract
We have characterized the changes in microtubule organization that occur through the cell division cycle of the fission yeast Scbizosaccbaro-tnyces pombe by indirect immunofluorescence microscopy. During interphase, groups of cytoplasmic microtubules, independent of the spindle pole body (SPB), form an array extending between the cell tips. These microtubules are involved in positioning the nucleus at the cell equator and in the establishment of cell polarity. At mitosis, the interphase array disappears and is replaced by an intranuclear spindle extending between the now duplicated SPBs. Elongation of the spindle sees the appearance of astral microtubules emanating from the cytoplasmic face of the SPBs. These persist until the end of anaphase whereupon the spindle microtubules depolymerize and two microtubule organizing centres (MTOCs) at the cell equator re-establish the interphase array. We have used the unique properties of various cell division cycle mutants to investigate further the function of these different microtubule arrays and their temporal and positional control.
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Cited by
[56] Molecular genetic analysis of fission yeast Schizosaccharomyces pombe
Moreno, S., Klar, A., & Nurse, P. (1991) · Methods in Enzymology · doi:10.1016/0076-6879(91)94059-l · Cited by 3,620
Novel potential mitotic motor protein encoded by the fission yeast cut7+ gene
Hagan, I., & Yanagida, M. (1990) · Nature · doi:10.1038/347563a0 · Cited by 353
Self-citationMata, J., & Nurse, P. (1997) · Cell · doi:10.1016/s0092-8674(00)80279-2 · Cited by 353
Kinesin-related cut 7 protein associates with mitotic and meiotic spindles in fission yeast
Hagan, I., & Yanagida, M. (1992) · Nature · doi:10.1038/356074a0 · Cited by 256
Self-citationDefective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit
Gordon, C., McGurk, G., Dillon, P., Rosen, C., & Hastie, N. D. (1993) · Nature · doi:10.1038/366355a0 · Cited by 236
Metadata
- Authors
- Hagan, I. M., & Hyams, J. S.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 1988-03-01
- Volume
- 89
- Issue
- 3
- Pages
- 343-357
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2311110868
- Cited by
- 489
- References
- 0
- FWCI
- 7.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The use of cell division cycle mutants to investigate the control of microtubule distribution in the fission yeast Schizosaccharomyces pombe. https://app.cochat.ai/papers/10.1242/jcs.89.3.343
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- Hagan, I. M., & Hyams, J. S. (1988). The use of cell division cycle mutants to investigate the control of microtubule distribution in the fission yeast Schizosaccharomyces pombe. Journal of Cell Science. https://doi.org/10.1242/jcs.89.3.343
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