The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals
Abstract
SUMMARY: Trehalose is a nonreducing disaccharide in which the two glucose units are linked in an α,α-1,1-glycosidic linkage. The best known and most widely distributed pathway of trehalose synthesis involves the transfer of glucose from UDP-glucose to glucose 6-phosphate to form trehalose-6-phosphate and UDP via the trehalose-6-phosphate synthase (TPS1). Trehalose-6-phosphate phosphatase (TPS2) then converts trehalose-6-phosphate to free trehalose. This sugar is present in a wide variety of organisms,including bacteria, yeast, fungi, insects, invertebrates and plants, and because of its particular physical features, trehalose is able to protect the integrity of cells against a variety of environmental stresses such as desiccation, dehydration, heat, cold and oxidation. Our current studies described here indicate that trehalose protects Drosophila and mammalian cells from hypoxic and anoxic injury. The mechanism of this protection is probably related to a decrease in protein denaturation through protein–trehalose interactions.
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Citations
Cites
New insights on trehalose: a multifunctional molecule
Elbein, A. D. (2003) · Glycobiology · doi:10.1093/glycob/cwg047 · Cited by 1,954
Trehalose accumulation in rice plants confers high tolerance levels to different abiotic stresses
Garg, A. K., Kim, J.-K., Owens, T. G., Ranwala, A. P., Choi, Y. D., Kochian, L. V., & Wu, R. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252637799 · Cited by 1,346
Multiple Effects of Trehalose on Protein Folding In Vitro and In Vivo
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Benaroudj, N., Lee, D. H., & Goldberg, A. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101487200 · Cited by 668
Why Is Trehalose an Exceptional Protein Stabilizer?
Kaushik, J. K., & Bhat, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300815200 · Cited by 625
Richards, A. B., Krakowka, S., Dexter, L. B., Schmid, H., Wolterbeek, A. P. M., Waalkens-Berendsen, D. H., Shigoyuki, A., & Kurimoto, M. (2002) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(02)00011-x · Cited by 593
Allison, S. D., Chang, B., Randolph, T. W., & Carpenter, J. F. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1175 · Cited by 546
The Metabolism of α,α-Trehalose
Elbein, A. D. (1974) · Advances in Carbohydrate Chemistry and Biochemistry · doi:10.1016/s0065-2318(08)60266-8 · Cited by 526
THE BIOSYNTHESIS OF TREHALOSE PHOSPHATE
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Trehalose expression confers desiccation tolerance on human cells
Guo, N., Puhlev, I., Brown, D. R., Mansbridge, J., & Levine, F. (2000) · Nature Biotechnology · doi:10.1038/72616 · Cited by 388
Cited by
Yancey, P. H. (2005) · Journal of Experimental Biology · doi:10.1242/jeb.01730 · Cited by 1,868
Sarkar, S., Davies, J. E., Huang, Z., Tunnacliffe, A., & Rubinsztein, D. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609532200 · Cited by 1,142
Sarkar, S., Ravikumar, B., Floto, R. A., & Rubinsztein, D. C. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2008.110 · Cited by 578
Sinclair, B. J., Ferguson, L. V., Salehipour-shirazi, G., & MacMillan, H. A. (2013) · Integrative and Comparative Biology · doi:10.1093/icb/ict004 · Cited by 308
Rodríguez-Navarro, J. A., Rodríguez, L., Casarejos, M. J., Solano, R. M., Gómez, A., Perucho, J., Cuervo, A. M., García de Yébenes, J., & Mena, M. A. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.05.014 · Cited by 298
Metadata
- Authors
- Chen, Q., & Haddad, G. G.
- Venue
- Journal of Experimental Biology
- Publisher
- The Company of Biologists
- Published
- 2004-08-15
- Volume
- 207
- Issue
- 18
- Pages
- 3125-3129
- ISSN
- 0022-0949 (ISSN-L)
- 1477-9145
- OpenAlex
- W2169052801
- Cited by
- 257
- References
- 22
- FWCI
- 10.11
- Type
- journal article
- Language
- en
- Open access
- closed
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