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The physiology of climate change: how potentials for acclimatization and genetic adaptation will determine ‘winners’ and ‘losers’

Somero, G. N.·2010·Journal of Experimental Biology
DOI 10.1242/jeb.037473
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Abstract

SUMMARY: Physiological studies can help predict effects of climate change through determining which species currently live closest to their upper thermal tolerance limits, which physiological systems set these limits, and how species differ in acclimatization capacities for modifying their thermal tolerances. Reductionist studies at the molecular level can contribute to this analysis by revealing how much change in sequence is needed to adapt proteins to warmer temperatures — thus providing insights into potential rates of adaptive evolution — and determining how the contents of genomes — protein-coding genes and gene regulatory mechanisms — influence capacities for adapting to acute and long-term increases in temperature. Studies of congeneric invertebrates from thermally stressful rocky intertidal habitats have shown that warm-adapted congeners are most susceptible to local extinctions because their acute upper thermal limits (LT50 values) lie near current thermal maxima and their abilities to increase thermal tolerance through acclimation are limited. Collapse of cardiac function may underlie acute and longer-term thermal limits. Local extinctions from heat death may be offset by in-migration of genetically warm-adapted conspecifics from mid-latitude ‘hot spots’, where midday low tides in summer select for heat tolerance. A single amino acid replacement is sufficient to adapt a protein to a new thermal range. More challenging to adaptive evolution are lesions in genomes of stenotherms like Antarctic marine ectotherms, which have lost protein-coding genes and gene regulatory mechanisms needed for coping with rising temperature. These extreme stenotherms, along with warm-adapted eurytherms living near their thermal limits, may be the major ‘losers’ from climate change.

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Research works printed but not linked: 60

  1. Barry, 1995, Climate-related, long-term faunal changes in a California rocky intertidal community, Science, 267, 672, 10.1126/science.267.5198.672 · DOI · Paper page
  2. Beere, 2004, ‘The stress of dying’: the role of heat shock proteins in the regulation of apoptosis, J. Cell Sci., 117, 2641, 10.1242/jcs.01284 · DOI · Paper page
  3. Braby, 2006, Following the heart: temperature and salinity effects on heart rate in native and invasive species of blue mussels (genus Mytilus), J. Exp. Biol., 209, 2554, 10.1242/jeb.02259 · DOI · Paper page
  4. Buckley, 2009, cDNA microarray analysis reveals the capacity of the cold-adapted Antarctic fish Trematomus bernacchii to alter gene expression in response to heat stress, Polar Biol., 32, 403, 10.1007/s00300-008-0533-x · DOI
  5. Buckley, 2006, The cellular response to heat stress in the goby Gillichthys mirabilis: a cDNA microarray and protein-level analysis, J. Exp. Biol., 209, 2660, 10.1242/jeb.02292 · DOI · Paper page
  6. Clark, 2009, HSP70 heat shock proteins and environmental stress in Antarctic marine organisms: a mini-review, Mar. Genom., 2, 11, 10.1016/j.margen.2009.03.003 · DOI · Paper page
  7. Clark, 2009, Lack of an HSP70 heat shock response in two Antarctic marine invertebrates, Polar Biol., 31, 1059, 10.1007/s00300-008-0447-7 · doi:10.1007/s00300-008-0447-7
  8. Cocca, 1997, Do the hemoglobinless icefishes have globin genes?, Comp. Biochem. Physiol. A, 118, 1027, 10.1016/S0300-9629(97)00010-8 · doi:10.1016/s0300-9629(97)00010-8
  9. Creagh, 2000, Heat shock proteins — modulators of apoptosis in tumour cells, Leukemia, 14, 1161, 10.1038/sj.leu.2401841 · DOI · Paper page
  10. Crummett, 2007, Genetic evidence for the cryptic species pair Lottia digitalis and Lottia austrodigitalis and microhabitat partitioning in sympatry, Mar. Biol., 152, 1, 10.1007/s00227-007-0621-4 · doi:10.1007/s00227-007-0621-4
  11. Dong, 2009, Temperature adaptation of cytosolic malate dehydrogenases of limpets (genus Lottia): differences in stability and function due to minor changes in sequence correlate with biogeographic and vertical distributions, J. Exp. Biol., 212, 169, 10.1242/jeb.024505 · DOI
  12. Eastman, 1993, Antarctic Fish Biology: Evolution in a Unique Environment
  13. Fangue, 2006, Intraspecific variation in thermal tolerance and heat shock protein gene expression in common killifish, Fundulus heteroclitus, J. Exp. Biol., 209, 2859, 10.1242/jeb.02260 · DOI · Paper page
  14. Fields, 2004, Decreases in activation energy and substrate affinity in cold-adapted A4-lactate dehydrogenases: evidence from the Antarctic notothenioid fish Chaenocephalus aceratus, Mol. Biol. Evol., 21, 2246, 10.1093/molbev/msh237 · DOI
  15. Fields, 1998, Hot spots in cold adaptation: localized increases in conformational flexibility in lactate dehydrogenase A4 orthologs of Antarctic notothenioid fishes, Proc. Natl. Acad. Sci. USA, 95, 11476, 10.1073/pnas.95.19.11476 · DOI · Paper page
  16. Fields, 2006, Temperature sensitivities of cytosolic malate dehydrogenases from native and invasive species of marine mussels (genus Mytilus): sequence-function linkages and correlations with biogeographic distribution, J. Exp. Biol., 209, 656, 10.1242/jeb.02036 · DOI
  17. Gilman, 2006, Variation in the sensitivity of organismal body temperature to climate change over local and geographic scales, Proc. Natl. Acad. Sci. USA, 103, 9560, 10.1073/pnas.0510992103 · DOI · Paper page
  18. Harrison, 2002, Studying genomes through the aeons: protein families, pseudogenes and proteome evolution, J. Mol. Biol., 318, 1155, 10.1016/S0022-2836(02)00109-2 · DOI · Paper page
  19. Helmuth, 2009, From cells to coastlines: how can we use physiology to forecast the impacts of climate change?, J. Exp. Biol., 212, 753, 10.1242/jeb.023861 · DOI · Paper page
  20. Helmuth, 2002, Climate change and latitudinal patterns of intertidal thermal stress, Science, 298, 1015, 10.1126/science.1076814 · DOI · Paper page
  21. Helmuth, 2006, Mosaic patterns of thermal stress in the rocky intertidal zone: implications for climate change, Ecol. Monogr., 76, 461, 10.1890/0012-9615(2006)076[0461:MPOTSI]2.0.CO;2 · DOI · Paper page
  22. Hochachka, 2002, Biochemical adaptation: mechanism and process in physiological evolution, 10.1093/oso/9780195117028.001.0001 · DOI · Paper page
  23. Hoffmann, 2008, Detecting genetic responses to environmental change, Nature Rev. Genet., 9, 421, 10.1038/nrg2339 · DOI · Paper page
  24. Hoffmann, 2003, Adaptation of Drosophila to temperature extremes: bringing together quantitative and molecular approaches, J. Therm. Biol., 28, 175, 10.1016/S0306-4565(02)00057-8 · DOI · Paper page
  25. Hofmann, 2000, Heat shock protein expression is absent in the Antarctic fish Trematomus bernacchii (Family Nototheniidae), J. Exp. Biol., 203, 2331, 10.1242/jeb.203.15.2331 · DOI · Paper page
  26. Holland, 1997, Evolution of lactate dehydrogenase-A homologs of barracuda fishes (Genus Sphyraena) from different thermal environments: differences in kinetic properties and thermal stability are due to amino acid substitutions outside the active site, Biochemistry, 36, 3207, 10.1021/bi962664k · DOI
  27. Hull, 1999, Heat stability and activity levels of aspartate aminotransferase and alanine aminotransferase in British Littorinidae, J. Exp. Mar. Biol. Ecol., 237, 255, 10.1016/S0022-0981(99)00006-4 · doi:10.1016/s0022-0981(99)00006-4
  28. Johns, 2004, Evolutionary convergence in adaptation of proteins to temperature: A4-lactate dehydrogenases of Pacific damselfishes (Chromis spp.), Mol. Biol. Evol., 21, 314, 10.1093/molbev/msh021 · doi:10.1093/molbev/msh021
  29. Kuo, 2009, Geographic variation in the upper thermal limits of an intertidal snail: implications for climate envelope models, Mar. Ecol. Prog. Ser., 388, 137, 10.3354/meps08102 · DOI · Paper page
  30. Meredith, 2005, Rapid climate change in the ocean west of the Antarctic Peninsula during the second half of the 20th century, Geophys. Letts., 32, L19604
  31. Montgomery, 2000, Disaptation and recovery in the evolution of Antarctic fishes, Trends Ecol. Evol., 15, 267, 10.1016/S0169-5347(00)01896-6 · DOI
  32. Murphy, 2005, Transient response of the Hadley Centre coupled ocean-atmosphere model to increasing carbon dioxide, J. Climate, 8, 496, 10.1175/1520-0442(1995)008<0496:TROTHC>2.0.CO;2 · DOI
  33. Panova, 2004, Microscale variation in Aat (aspartate aminotransferase) is supported by activity differences between upper and lower shore allozymes of Littorina saxitalis, Mar. Biol., 144, 1157, 10.1007/s00227-003-1274-6 · doi:10.1007/s00227-003-1274-6
  34. Peck, 2004, Extreme sensitivity of biological function to temperature in Antarctic marine species, Func. Ecol., 18, 625, 10.1111/j.0269-8463.2004.00903.x · DOI · Paper page
  35. Peck, 2009, Lack of acclimation in Ophionotus victoriae: brittle stars are not fish, Polar Biol., 32, 399, 10.1007/s00300-008-0532-y · DOI
  36. Podrabsky, 2004, Changes in gene expression associated with acclimation to constant and fluctuating daily temperatures in an annual killfish Austrofundulus limnaeus, J. Exp. Biol., 207, 2237, 10.1242/jeb.01016 · DOI · Paper page
  37. Podrabsky, 2006, Inducible heat tolerance in Antarctic notothenioid fishes, Polar Biol., 30, 39, 10.1007/s00300-006-0157-y · doi:10.1007/s00300-006-0157-y
  38. Pörtner, 2002, Climate variations and the physiological basis of temperature dependent biogeography: systemic to molecular hierarchy of thermal tolerance in animals, Comp. Biochem. Physiol. A, 132, 739, 10.1016/S1095-6433(02)00045-4 · DOI · Paper page
  39. Pörtner, 2006, Thermal limits and adaptation in marine Antarctic ectotherms: an integrative view, Phil. Trans. R. Soc. B., 362, 2233, 10.1098/rstb.2006.1947 · DOI · Paper page
  40. Pratt, 1997, The role of the hsp90-based chaperone system in signal transduction by nuclear receptors and receptors signalling via MAP kinase, Annu. Rev. Pharmacol. Toxicol., 37, 297, 10.1146/annurev.pharmtox.37.1.297 · DOI · Paper page
  41. Rudd, 1954, Vertebrates without erythrocytes and blood pigment, Nature, 173, 848, 10.1038/173848a0 · DOI · Paper page
  42. Savolainen, 2007, Gene flow and local adaptation in trees, Annu. Rev. Ecol. Evol. Syst., 38, 595, 10.1146/annurev.ecolsys.38.091206.095646 · DOI · Paper page
  43. Schmidt, 2001, Adaptive maintenance of genetic polymorphism in an intertidal barnacle: habitat- and life-stage-specific survivorship of mpi genotypes, Evolution, 55, 1336, 10.1111/j.0014-3820.2001.tb00656.x · DOI
  44. Sidell, 2006, When bad things happen to a good fish: the loss of hemoglobin and myoglobin expression in Antarctic icefishes, J. Exp. Biol., 209, 1791, 10.1242/jeb.02091 · DOI · Paper page
  45. Sidell, 1997, Variable expression of myoglobin among the hemoglobinless Antarctic icefishes, Proc. Natl. Acad. Sci. USA, 94, 3420, 10.1073/pnas.94.7.3420 · DOI
  46. Somero, 2002, Thermal physiology and vertical zonation of intertidal animals: optima, limits and cost of living, Integr. Comp. Biol., 42, 780, 10.1093/icb/42.4.780 · DOI · Paper page
  47. Somero, 2004, Temperature adaptation of proteins: searching for basic “strategies”, Comp. Biochem. Physiol., 139, 321, 10.1016/j.cbpc.2004.05.003 · DOI · Paper page
  48. Somero, 2005, Linking biogeography to physiology: evolutionary and acclimatory adjustments of thermal limits, Front. Zool., 2, 1, 10.1186/1742-9994-2-1 · DOI · Paper page
  49. Somero, 1967, Temperature tolerance of some Antarctic fishes, Science, 156, 257, 10.1126/science.156.3772.257 · DOI · Paper page
  50. Stachowicz, 2002, Linking climate change and biological invasions: ocean warming facilitates nonindigenous species invasions, Proc. Natl. Acad. Sci. USA, 99, 15497, 10.1073/pnas.242437499 · DOI · Paper page
  51. Stenseng, 2005, Evolutionary and acclimation-induced variation in the thermal limits of heart function in congeneric marine snails (genus Tegula): implications for vertical zonation, Biol. Bull., 208, 138, 10.2307/3593122 · doi:10.2307/3593122
  52. Stillman, 2002, Causes and consequences of thermal tolerance limits in rocky intertidal porcelain crabs, genus Petrolisthes, Integ. Comp. Biol., 42, 790, 10.1093/icb/42.4.790 · DOI · Paper page
  53. Stillman, 2003, Acclimation capacity underlies susceptibility to climate change, Science, 301, 65, 10.1126/science.1083073 · DOI · Paper page
  54. Stillman, 1996, Adaptation to temperature stress and aerial exposure in congeneric species of intertidal porcelain crabs (genus Petrolisthes): correlation of physiology, biochemistry and morphology with vertical distribution, J. Exp. Biol., 199, 1845, 10.1242/jeb.199.8.1845 · DOI · Paper page
  55. Stillman, 2000, A comparative analysis of the upper thermal tolerance limits of eastern Pacific porcelain crabs, Genus Petrolisthes: influences of latitude, vertical zonation, acclimation and phylogeny, Physiol. Biochem. Zool., 73, 200, 10.1086/316738 · DOI · Paper page
  56. Storch, 2009, Thermal tolerance of crustacean larvae (zoea I) in two different populations of the kelp crab Taliepus dentatus (Milne-Edwards), J. Exp. Biol., 212, 1371, 10.1242/jeb.030205 · DOI
  57. Tewksbury, 2008, Putting the heat on tropical animals, Science, 320, 1296, 10.1126/science.1159328 · DOI · Paper page
  58. Tomanek, 1999, Evolutionary and acclimation-induced variation in the heat-shock responses of congeneric marine snails (genus Tegula) from different thermal habitats: implications for limits of thermotolerance and biogeography, J. Exp. Biol., 202, 2925, 10.1242/jeb.202.21.2925 · DOI · Paper page
  59. Watt, 2000, Molecular-functional studies of adaptive genetic variation in prokaryotes and eukaryotes, Annu. Rev. Genet., 34, 593, 10.1146/annurev.genet.34.1.593 · DOI
  60. Wolcott, 1973, Physiological ecology and intertidal zonation in limpets (Acmaea): a critical look at “limiting factors”, Biol. Bull., 145, 389, 10.2307/1540048 · DOI · Paper page

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Metadata

Authors
Somero, G. N.
Venue
Journal of Experimental Biology
Publisher
The Company of Biologists
Published
2010-03-15
Volume
213
Issue
6
Pages
912-920
ISSN
  • 0022-0949 (ISSN-L)
  • 1477-9145
DOI
10.1242/jeb.037473
OpenAlex
W2123111228
Cited by
1,892
References
3
FWCI
66.63
Type
journal article
Language
en
Open access
closed

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Somero, G. N. (2010). The physiology of climate change: how potentials for acclimatization and genetic adaptation will determine ‘winners’ and ‘losers’. Journal of Experimental Biology. https://doi.org/10.1242/jeb.037473

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