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Oocyte apoptosis during the transition from ovary-like tissue to testes during sex differentiation of juvenile zebrafish
Abstract
SUMMARY: Large numbers of apoptotic early diplotene oocytes were observed during the transition from ovary-like undifferentiated gonadal tissue to testes during sex differentiation in presumptive males of the zebrafish (Danio rerio). The percentage of terminal-deoxynucleotidyl-transferase-mediated dUTP nick-end labelling (TUNEL)-positive apoptotic oocytes in the gonads of presumptive males was approximately eight- to 12-fold higher than in genetic all-females. By 29 days post-hatching, all oocytes had disappeared from the gonads of presumptive males. In these males, we also observed apoptotic somatic cells in the ovarian cavity between 23 and 35 days post-hatching. Therefore, the disappearance of oocytes and the decomposition of the ovarian cavity caused by apoptosis during sex differentiation were male-specific events. In genetic all-females, apoptosis in a proportion of early diplotene oocytes was found in the undifferentiated gonads at 15–19 days post-hatching, probably as a result of programmed oocyte loss during ovarian development. These findings suggest that oocyte apoptosis is the mechanism of testicular and ovarian differentiation in zebrafish.
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Cited by
Rodríguez-Marí, A., Yan, Y.-L., BreMiller, R. A., Wilson, C., Cañestro, C., & Postlethwait, J. H. (2005) · Gene Expression Patterns · doi:10.1016/j.modgep.2005.02.008 · Cited by 396
Sex determination, gonadal sex differentiation, and plasticity in vertebrate species
Nagahama, Y., Chakraborty, T., Paul-Prasanth, B., Ohta, K., & Nakamura, M. (2021) · Physiological Reviews · doi:10.1152/physrev.00044.2019 · Cited by 346
Wild Sex in Zebrafish: Loss of the Natural Sex Determinant in Domesticated Strains
Wilson, C. A., High, S. K., McCluskey, B. M., Amores, A., Yan, Y.-L., Titus, T. A., Anderson, J. L., Batzel, P., Carvan, M. J., Schartl, M., et al. (2014) · Genetics · doi:10.1534/genetics.114.169284 · Cited by 331
Örn, S., Holbech, H., Madsen, T. H., Norrgren, L., & Petersen, G. I. (2003) · Aquatic Toxicology · doi:10.1016/s0166-445x(03)00177-2 · Cited by 300
Fenske, M., Maack, G., Schäfers, C., & Segner, H. (2005) · Environmental Toxicology and Chemistry · doi:10.1897/04-096r1.1 · Cited by 179
Metadata
- Authors
- Uchida, D., Yamashita, M., Kitano, T., & Iguchi, T.
- Venue
- Journal of Experimental Biology
- Publisher
- The Company of Biologists
- Published
- 2002-03-15
- Volume
- 205
- Issue
- 6
- Pages
- 711-718
- ISSN
- 0022-0949 (ISSN-L)
- 1477-9145
- OpenAlex
- W2266093504
- Cited by
- 415
- References
- 0
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Oocyte apoptosis during the transition from ovary-like tissue to testes during sex differentiation of juvenile zebrafish. https://app.cochat.ai/papers/10.1242/jeb.205.6.711
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- Uchida, D., Yamashita, M., Kitano, T., & Iguchi, T. (2002). Oocyte apoptosis during the transition from ovary-like tissue to testes during sex differentiation of juvenile zebrafish. Journal of Experimental Biology. https://doi.org/10.1242/jeb.205.6.711
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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