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Photokilling of Malignant Cells with Ultrafine TiO2 Powder
Abstract
Photo-irradiated TiO2 particles drive various chemical reactions due to their strong oxidation and reduction ability. This effect is applied in order to kill malignant HeLa cells with TiO2 particles. During 10-min UV irradiation periods, HeLa cells were completely killed in the presence of TiO2 (100 μg cm−3). However, without irradiation these particles showed little cytotoxicity up to 360 μg cm−3. It is concluded that the cells were killed by hydroxyl (OH·) and perhydroxyl (HO2·) radicals produced from water by the irradiated TiO2 particles, and also that the cells were directly oxidized by photogenerated holes in TiO2. The distribution of TiO2 powders in the cells was observed using a transmission electron microscope. The TiO2 powder existed not only on the cell membrane, but also in the cytoplasm. Thus, the cells were damaged by photoexcited TiO2 not only from the cell membrane, but also from the inside of cytoplasm. Finally, the application of this malignant cell photokilling effect to photodynamic therapy is discussed.
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Citations
Cited by
The surface science of titanium dioxide
Diebold, U. (2003) · Surface Science Reports · doi:10.1016/s0167-5729(02)00100-0 · Cited by 7,944
TiO2 photocatalysis and related surface phenomena
FUJISHIMA, A., ZHANG, X., & TRYK, D. (2008) · Surface Science Reports · doi:10.1016/j.surfrep.2008.10.001 · Cited by 6,737
Self-citationTiO2 photocatalysis: Design and applications
Nakata, K., & Fujishima, A. (2012) · Journal of Photochemistry and Photobiology C: Photochemistry Reviews · doi:10.1016/j.jphotochemrev.2012.06.001 · Cited by 3,651
Self-citationInorganic and organic UV filters: Their role and efficacy in sunscreens and suncare products
Serpone, N., Dondi, D., & Albini, A. (2007) · Inorganica Chimica Acta · doi:10.1016/j.ica.2005.12.057 · Cited by 711
Grey Goo on the Skin? Nanotechnology, Cosmetic and Sunscreen Safety
Nohynek, G. J., Lademann, J., Ribaud, C., & Roberts, M. S. (2007) · Critical Reviews in Toxicology · doi:10.1080/10408440601177780 · Cited by 644
Metadata
- Authors
- Cai, R., Hashimoto, K., Itoh, K., Kubota, Y., & Fujishima, A.
- Venue
- Bulletin of the Chemical Society of Japan
- Publisher
- Oxford University Press (OUP)
- Published
- 1991-04-01
- Volume
- 64
- Issue
- 4
- Pages
- 1268-1273
- ISSN
- 0009-2673 (ISSN-L)
- 1348-0634
- OpenAlex
- W1979284608
- Cited by
- 242
- References
- 0
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cai, R., Hashimoto, K., Itoh, K., Kubota, Y., & Fujishima, A. (1991). Photokilling of Malignant Cells with Ultrafine TiO2 Powder. Bulletin of the Chemical Society of Japan. https://doi.org/10.1246/bcsj.64.1268
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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