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Cited by 17Natural Antidiabetic Agents StudiesTrace Elements in HealthMetal complexes synthesis and properties

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Antidiabetic Activity of Zn(II) Complexes with a Derivative of l-Glutamine

Matsumoto, Kinuyo, Yamamoto, Shuhei, Yoshikawa, Yutaka, Doe, Matsumi, Kojima, Yoshitane, Sakurai, Hiromu, Hashimoto, Hiroko, Kajiwara, Naemi M·2005·Bulletin of the Chemical Society of Japan
DOI 10.1246/bcsj.78.1077
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Abstract

The insulinomimetic activity of zinc(II) complexes Zn(gln-m)2 and Zn(gln-e)2, respectively, with l-γ-glutamyl-methylamide (gln-m) and -ethylamide (theanine: gln-e), components of green tea, were compared to that of Zn(gln)2 with l-glutamine (gln) in an in vitro study using isolated rodent adipocytes treated with epinephrine in the presence of glucose, expressed as the IC50 value (50% inhibition concentration) of free fatty acids (FFA) released from fat cells. The former were found to have higher inslinomimetic activity than that of the latter. The IC50 values of the former were 0.61 and 0.56, respectively. Then, the anti-diabetic activity of a zinc(II) complex, Zn(gln-e)2, was examined in an in vivo experiment on KK-Ay mice, model animals of type-2 DM, by the intraperitoneal (ip) injection of 3–4 mg Zn/kg b.w./day for 13 days. The blood-glucose level of a group treated with a Zn complex, Zn(gln-e)2, decreased significantly after 13 days compared to those of non-treated and gln-e treated groups. The serum concentrations of triglyceride (TG) and HbA1c decreased significantly in Zn(gln-e)2 treated KK-Ay mice compared to those of the gln-e treated group, respectively. Furthermore, the improvement in glucose tolerance was confirmed by an oral glucose tolerance test.

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Crossref · 10.1246/bcsj.78.1077

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Metadata

Authors
Matsumoto, K., Yamamoto, S., Yoshikawa, Y., Doe, M., Kojima, Y., Sakurai, H., Hashimoto, H., & Kajiwara, N. M.
Affiliations
  • Kobe Women's University (JP)
  • Osaka City University (JP)
  • Kyoto Pharmaceutical University (JP)
ORCID
Venue
Bulletin of the Chemical Society of Japan
Publisher
Oxford University Press (OUP)
Published
2005-06-01
Volume
78
Issue
6
Pages
1077-1081
ISSN
  • 0009-2673 (ISSN-L)
  • 1348-0634
DOI
10.1246/bcsj.78.1077
OpenAlex
W2091230732
Cited by
17
References
30
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2022: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2015: 2
FWCI
0.21
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
Bulletin of the Chemical Society of Japan (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
Keywords
zinc(II) complexes, theanine, insulin-like activity, antidiabetic activity, type 2 diabetes, KK-Ay mice, adipocytes, free fatty acid release, glucose tolerance, blood glucose, triglycerides, HbA1c

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