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Molecular Mechanism to Maintain Stem Cell Renewal of ES Cells.
Open accessAbstract
Embryonic stem (ES) cells are pluripotent cells directly derived from early stage embryos that retain the ability to differentiate into all cell types. This unique feature is the basis of various applications of ES cell technology such as in vitro models of mammalian development, germline transgenesis to make knockout mice, and a generic source for cell therapy in regenerative medicine. To achieve success in these applications, the pluripotency of ES cells has to be kept stable during long-term culture in vitro, leading to the necessity of determining the molecular basis for maintaining ES self-renewal. This paper summarizes the recent progress in this area, focusing mainly on the LIF signaling pathway and the transcription factor Oct-3/4. Although it is still unclear how these components works together, a model is presented here that provides a plan to solve this problem.
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Cited by
Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells
Boyer, L. A., Lee, T. I., Cole, M. F., Johnstone, S. E., Levine, S. S., Zucker, J. P., Guenther, M. G., Kumar, R. M., Murray, H. L., Jenner, R. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.020 · Cited by 4,505
Sato, N., Meijer, L., Skaltsounis, L., Greengard, P., & Brivanlou, A. H. (2004) · Nature Medicine · doi:10.1038/nm979 · Cited by 2,109
Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue
Izadpanah, R., Trygg, C., Patel, B., Kriedt, C., Dufour, J., Gimble, J. M., & Bunnell, B. A. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20904 · Cited by 670
Metadata
- Authors
- Niwa, H.
- Venue
- Cell Structure and Function
- Publisher
- Japan Society for Cell Biology
- Published
- 2001
- Volume
- 26
- Issue
- 3
- Pages
- 137-148
- ISSN
- 0386-7196 (ISSN-L)
- 1347-3700
- OpenAlex
- W2026443209
- Cited by
- 287
- References
- 0
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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