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Anti-HIV-1 Activity of Herbs in Labiatae.
Open accessAbstract
The anti-HIV-1 activity of aromatic herbs in Labiatae was evaluated in vitro. Forty five extract from among 51 samples obtained from 46 herb species showed significant inhibitory effects against HIV-1 induced cytopathogenicity in MT-4 cells. In particular, the aqueous extracts of Melissa officinalis, a family of Mentha x piperita "grapefruit mint," Mentha x piperita var. crispa, Ocimum basilicum cv "cinnamon," Perilla frutescens var. crispa f. viridis, Prunella vulgaris subsp. asiatica and Satureja montana showed potent anti-HIV-1 activity (with an ED of 16 microg/ml). The active components in the extract samples were found to be water-soluble polar substances, not nonpolar compounds such as essential oils. In addition, these aqueous extracts inhibited giant cell formation in co-culture of Molt-4 cells with and without HIV-1 infection and showed inhibitory activity against HIV-1 reverse transcriptase.
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Citations
Cited by
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Ethnomedicinal, Phytochemical and Pharmacological Investigations of Perilla frutescens (L.) Britt.
Ahmed, H. M. (2018) · Molecules · doi:10.3390/molecules24010102 · Cited by 266
Chemical composition and antioxidant and antimicrobial activity of two Satureja essential oils
Ćavar, S., Maksimović, M., Šolić, M. E., Jerković-Mujkić, A., & Bešta, R. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.04.033 · Cited by 214
Metadata
- Authors
- YAMASAKI, K., NAKANO, M., KAWAHATA, T., MORI, H., OTAKE, T., UEDA, N., OISHI, I., INAMI, R., YAMANE, M., NAKAMURA, M., MURATA, H., & NAKANISHI, T.
- Venue
- Biological and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 1998
- Volume
- 21
- Issue
- 8
- Pages
- 829-833
- ISSN
- 0918-6158 (ISSN-L)
- 1347-5215
- OpenAlex
- W2043052489
- Cited by
- 252
- References
- 0
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- YAMASAKI, K., NAKANO, M., KAWAHATA, T., MORI, H., OTAKE, T., UEDA, N., OISHI, I., INAMI, R., YAMANE, M., NAKAMURA, M., MURATA, H., & NAKANISHI, T. (1998). Anti-HIV-1 Activity of Herbs in Labiatae. Biological and Pharmaceutical Bulletin. https://doi.org/10.1248/bpb.21.829
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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