The anti-thrombotic active constituents from Centella asiatica
Open accessAbstract
The in vitro effects of a methanol extract from the aerial parts of Centella asiatica on shear-induced platelet activation and coagulation were assessed after oral administration to rats, by subjecting non-anticoagulated blood to haemostatometry. 3,5-Di-O-caffeoyl quinic acid, 1,5-di-O-caffeoyl quinic acid, 3,4-di-O-caffeoyl quinic acid, 4,5-di-O-caffeoyl quinic acid, and chlorogenic acid, together with asiaticoside, kaempferol, quercetine, kaempferol-3-O-beta-D-glucoside and quercetin-3-O-beta-D-glucoside were all isolated from the methanol extract. Amongst these, only 3,5-di-O-caffeoylquinic acid showed significant inhibition of shear-induced platelet activation and dynamic coagulation. The reactive curve of the inhibitory effect on the platelet reaction and the dynamic coagulation showed a bell-shape.
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Caffeoylquinic acids found in CA induce Nrf2 and Ho-1 signaling and positively impact glutathione levels.
“Caffeoylquinic acids found in CA [28,96,97], are also known to induce Nrf2 and Ho-1 signaling, and positively impact glutathione levels [98,99].”
From Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice (2019) · cites this paper as [97]
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References 28 · Cited by 118
Research works printed but not linked: 2
- Joshi S. G., "Medicinal Plants," Oxford & IBH Publishing Co., Pvt. Ltd., New Delhi, 2000, p. 31.
- Mahato S. B., Sahu N. P., Luger P., Muller E., J. Chem. Soc., Perkin Trans. 1, 1987, 1509-1515 (1987).
- Authors
- Satake, T., Kamiya, K., An, Y., Oishi(nee Taka), T., & Yamamoto, J.
- Affiliations
- Kobe Gakuin University (JP)
- Faculty of Nutrition, Kobe Gakuin University
- ORCID
- Yamamoto, Junichiro
- Venue
- Biological and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2007
- Volume
- 30
- Issue
- 5
- Pages
- 935-940
- ISSN
- 0918-6158 (ISSN-L)
- 1347-5215
- OpenAlex
- W2053837068
- Cited by
- 118
- References
- 28
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 11 · 2023: 6 · 2022: 4 · 2021: 6 · 2020: 7 · 2019: 8 · 2018: 2 · 2017: 7 · 2016: 11 · 2015: 8 · 2014: 7 · 2013: 7 · 2012: 8
- FWCI
- 11.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biological and Pharmaceutical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kobe Gakuin University
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- Centella asiatica, antithrombotic activity, platelet activation, coagulation inhibition, caffeoylquinic acids, chlorogenic acid, asiaticoside, kaempferol, quercetin, flavonoids, methanol extract, hemostasis
- MeSH terms
- Administration, Oral, Methanol, Animals, Blood Coagulation, Blood Coagulation Tests, Blood Platelets, Fibrinolytic Agents, Male, Plant Extracts, Structure-Activity Relationship, Molecular Structure, Platelet Activation, Rats, Wistar, Centella, Plant Components, Aerial, Rats
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