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Cited by 6

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Distribution of Dolichol in the Serum and Relationships between Serum Dolichol Levels and Various Laboratory Test Values

Shiota, Yasuo, Kiyota, Kengo, Kobayashi, Teruaki, Kano, Shojiro, Kawamura, Mitsunobu, Matsushima, Teruhiko, Miyazaki, Shigeru, Uchino, Katsuyoshi, Hashimoto, Fumie, Hayashi, Hidenori·2008·Biological and Pharmaceutical Bulletin
DOI 10.1248/bpb.31.340
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Abstract

We examined the correlations between serum dolichol levels and laboratory test parameters in patients affected by disease, as well as the distribution of dolichol in sera from patients with hyperbetalipoproteinemia and hyperalphalipoproteinemia. Serum dolichol was evaluated by a reverse-phase HPLC method. After centrifugation, the serum dolichol found in healthy controls was mainly associated with medium-sized particles of the high-density lipoprotein (HDL) fraction. For patients with hyperbetalipoproteinemia, serum dolichol was also associated with the medium HDL fractions. However, for hyperalphalipoproteinemia patients the levels of large HDL and serum dolichol were increased, and serum dolichol was mainly associated with the large HDL fraction. On laboratory tests of components, the dolichol level was not correlated with the values for markers of the liver and biliary system, with the values of renal function markers, with creatine kinase activity, amylase activity or uric acid concentration, but was correlated with total cholesterol, HDL-cholesterol and apoA-I concentrations, and with lactate dehydrogenase (LDH) activity. These results suggest that serum dolichol exclusively localized in HDL, and in subpopulation, that in normocholesterolemia or hyperbeta-cholesterolemia is associated with HDL(3), which is small sized and high density HDL, however, that in hyperalphacholesterolemia is associated with HDL(2), which is large sized and lower density HDL.

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  1. 1985, Acta Chem. Scand. B, 39, 323
  2. Kurup R. K., Kurup P. A., 2003, Pediatr. Pathol. Mol. Med., 22, 423

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Metadata

Authors
Shiota, Y., Kiyota, K., Kobayashi, T., Kano, S., Kawamura, M., Matsushima, T., Miyazaki, S., Uchino, K., Hashimoto, F., & Hayashi, H.
Affiliations
  • Faculty of Pharmaceutical Sciences, Josai University
  • Department of Clinical Laboratory, Tokyo Teishin Hospital
  • Department of Internal Medicine, Tokyo Teishin Hospital
  • Department of Internal Medicine, Tsukuba Memorial Hospital
  • Department of Pharmacy, Tokyo Teishin Hospital
Venue
Biological and Pharmaceutical Bulletin
Publisher
Pharmaceutical Society of Japan
Published
2008
Volume
31
Issue
3
Pages
340-347
ISSN
  • 0918-6158
  • 1347-5215
DOI
10.1248/bpb.31.340
Cited by
6
References
38
Language
en

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