The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Prostaglandin E2 and Pain-An Update
Open accessAbstract
Prostaglandin E(2) (PGE(2)), a cyclooxygenase (COX) product, is the best known lipid mediator that contributes to inflammatory pain. Nonsteroidal anti-inflammatory drugs (NSAIDs), inhibitors of COX-1 and/or COX-2, suppress inflammatory pain by reducing generation of prostanoids, mainly PGE(2), while they exhibit gastrointestinal, renal and cardiovascular toxicities. Selective inhibitors of microsomal PGE synthase-1 and subtype-selective antagonists of PGE(2) receptors, particularly EP(1) and EP(4), may be useful as analgesics with minimized side-effects. Protein kinase C (PKC) and PKA downstream of EP(1) and EP(4), respectively, sensitize/activate multiple molecules including transient receptor potential vanilloid-1 (TRPV1) channels, purinergic P2X3 receptors, and voltage-gated calcium or sodium channels in nociceptors, leading to hyperalgesia. PGE(2) is also implicated in neuropathic and visceral pain and in migraine. Thus, PGE(2) has a great impact on pain signals, and pharmacological intervention in upstream and downstream signals of PGE(2) may serve as novel therapeutic strategies for the treatment of intractable pain.
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Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial
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Sensitization of TRPV1 by EP1 and IP Reveals Peripheral Nociceptive Mechanism of Prostaglandins
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Role of voltage-gated calcium channels in ascending pain pathways
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Chen, H., Hu, B., Lv, X., Zhu, S., Zhen, G., Wan, M., Jain, A., Gao, B., Chai, Y., Yang, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-08097-7 · Cited by 321
Menstruation pulls the trigger for inflammation and pain in endometriosis
Laux-Biehlmann, A., d’Hooghe, T., & Zollner, T. M. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.03.004 · Cited by 150
Mast cells, versatile gatekeepers of pain
Chatterjea, D., & Martinov, T. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2014.03.001 · Cited by 110
Benedetti, F., Durando, J., & Vighetti, S. (2014) · Pain · doi:10.1016/j.pain.2014.01.016 · Cited by 109
Identification of novel mechanisms involved in generating localized vulvodynia pain
Falsetta, M. L., Foster, D. C., Woeller, C. F., Pollock, S. J., Bonham, A. D., Haidaris, C. G., Stodgell, C. J., & Phipps, R. P. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.02.002 · Cited by 69
Metadata
- Authors
- Kawabata, A.
- Venue
- Biological and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2011
- Volume
- 34
- Issue
- 8
- Pages
- 1170-1173
- ISSN
- 0918-6158 (ISSN-L)
- 1347-5215
- OpenAlex
- W1978958738
- Cited by
- 332
- References
- 47
- FWCI
- 11.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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