Ginger Orally Disintegrating Tablets to Improve Swallowing in Older People
Open accessAbstract
We previously prepared and pharmaceutically evaluated ginger orally disintegrating (OD) tablets, optimized the base formulation, and carried out a clinical trial in healthy adults in their 20 s and 50s to measure their effect on salivary substance P (SP) level and improved swallowing function. In this study, we conducted clinical trials using the ginger OD tablets in older people to clinically evaluate the improvements in swallowing function resulting from the functional components of the tablet. The ginger OD tablets were prepared by mixing the excipients with the same amount of mannitol and sucrose to a concentration of 1% ginger. Eighteen healthy older adult volunteers aged 63 to 90 were included in the swallowing function test. Saliva was collected before and 15 min after administration of the placebo and ginger OD tablets. Swallowing endoscopy was performed by an otolaryngologist before administration and 15 min after administration of the ginger OD tablets. A scoring method was used to evaluate the endoscopic swallowing. Fifteen minutes after taking the ginger OD tablets, the salivary SP amount was significantly higher than prior to ingestion or after taking the placebo (p<0.05). Among 10 subjects, one scored 1-3 using the four evaluation criteria. Overall, no aspiration occurred and a significant improvement in the swallowing function score was observed (p<0.05) after taking the ginger OD tablets. Our findings showed that the ginger OD tablets increased the salivary SP amount and improved swallowing function in older people with appreciably reduced swallowing function.
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Salivary concentrations of substance P and swallowing function scores improve after ginger supplementation.
“In addition, salivary concentrations of substance P and swallowing function scores have improved after ginger supplementation [17].”
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Foshati, S., Poursadeghfard, M., Heidari, Z., & Amani, R. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04227-x · Cited by 11 · see citing works
“In addition, salivary concentrations of substance P and swallowing function scores have improved after ginger supplementation [17].”
Background
- Authors
- Hirata, A., Funato, H., Nakai, M., Iizuka, M., Abe, N., Yagi, Y., Shiraishi, H., Jobu, K., Yokota, J., Hirose, K., Hyodo, M., & Miyamura, M.
- Affiliations
- Kochi Medical School Hospital (JP)
- Department of Pharmacy, Kochi Medical School Hospital
- Venue
- Biological & Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2016
- Volume
- 39
- Issue
- 7
- Pages
- 1107-1111
- ISSN
- 0918-6158 (ISSN-L)
- 1347-5215
- OpenAlex
- W2470542151
- Cited by
- 17
- References
- 1
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2016: 1
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Biological and Pharmaceutical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (15K16189)
- Topics
- Health Sciences › Health Professions › Speech and Hearing › Dysphagia Assessment and Management
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Ginger and Zingiberaceae research
- Health Sciences › Medicine › Complementary and alternative medicine › Medical Research and Treatments
- Keywords
- ginger, orally disintegrating tablets, dysphagia, swallowing function, older adults, mannitol, sucrose, aspiration
- MeSH terms
- Administration, Oral, Aged, Aged, 80 and over, Catechols, Deglutition, Excipients, Fatty Alcohols, Female, Humans, Male, Mannitol, Middle Aged, Powders, Saliva, Solubility, Substance P, Sucrose, Tablets, Zingiber officinale, Plant Preparations, TRPV Cation Channels
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