Influence of Alkylamides of Glutamic Acid and Related Compounds on the Central Nervous System. I. Central Depressant Effect of Theanine
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Theanine (N-ethylglutamine), a flavourous constituent of tea leaves, was studied in respect of the influence on the central nervous system in mice.Theanine was shown to inhibit the convulsive action of caffeine, but was ineffective against pentetrazole, picrotoxin, strychnine, pipradrol and bemegride as well as L-glutamine. Neither theanine nor L-glutamine effected on the prolongation of the sleeping time after the injection of hexobarbital sodium in mice. Using 14C-labeled theanine, it was found that the intraperitoneally administered theanine was taken up by brain tissue with out undergoing the metabolic changes in a 30minutes. The intracerebral level of γaminobutyric acid was shown to increase significantly at 30minutes following the intraperitoneal administration of theanine in mice.
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L-theanine increases gamma-aminobutyric acid (GABA) following intraperitoneal administration to mice.
“increase gamma-aminobutyric acid (GABA) following intraperitoneal administration to mice”
From A Double-Blind, Placebo-Controlled Study Evaluating the Effects of Caffeine and L-Theanine Both Alone and in Combination on Cerebral Blood Flow, Cognition and Mood (2015) · cites this paper as Kimura and Murata 1971
Theanine increases GABA, an inhibitory neurotransmitter.
“It increases GABA, an inhibitory neurotransmitter.22”
From Theanine maintains sleep quality in healthy young women by suppressing the increase in caffeine-induced wakefulness after sleep onset (2023) · cites this paper as [22]
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References 1 · Cited by 98
Research works printed but not linked: 10
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- Authors
- KIMURA, R., & MURATA, T.
- Affiliations
- University of Shizuoka (JP)
- Venue
- Chemical and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 1971
- Volume
- 19
- Issue
- 6
- Pages
- 1257-1261
- ISSN
- 0009-2363 (ISSN-L)
- 1347-5223
- OpenAlex
- W2089586050
- Cited by
- 98
- References
- 1
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 2 · 2020: 1 · 2019: 5 · 2018: 6 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Chemical and Pharmaceutical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- theanine, central nervous system depressant effects, caffeine antagonism, convulsant activity, glutamine, brain uptake, GABA, tea constituents
- MeSH terms
- Amides, Amino Acids, Animals, Bemegride, Brain, Brain Chemistry, Caffeine, Carbon Isotopes, Central Nervous System, Depression, Chemical, Glutamine, Hexobarbital, Liver, Male, Pentylenetetrazole, Picrotoxin, Piperidines, Seizures, Sleep, Strychnine, Mice
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