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Growth-inhibitory effect of hexa-N-acetylchitohexaose and chitohexaose against Meth-A solid tumor.
Open accessAbstract
Two oligosaccharides, hexa-N-acetylchitohexaose (NACOS-6) and chitohexaose (COS-6), consisting solely of N-acetyl-D-glucosamine and D-glucosamine, respectively, were found to be growth-inhibitory against Meth-A solid tumor transplanted into BALB/c mice, when each oligosaccharide was administered i.v. at a dose of more than 1 mg/kg. Mouse peritoneal macrophages elicited with casein underwent activation with these oligosaccharides in vitro to produce interleukin 1. Spleen cells from mice given these oligosaccharides also underwent acceleration of interleukin 2 production and cytolytic T-lymphocyte differentiation. Thus, the antitumor mechanism of NACOS-6 and COS-6 was assumed to involve increased production of lymphokines including interleukins 1 and 2, sequentially, leading to the manifesation of antitumor effect through proliferation of cytolytic T-lymphocytes.
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Metadata
- Authors
- TOKORO, A., TAKEWAKI, N., SUZUKI, K., MIKAMI, T., SUZUKI, S., & SUZUKI, M.
- Venue
- Chemical and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 1988
- Volume
- 36
- Issue
- 2
- Pages
- 784-790
- ISSN
- 0009-2363 (ISSN-L)
- 1347-5223
- OpenAlex
- W2032087142
- Cited by
- 281
- References
- 0
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Growth-inhibitory effect of hexa-N-acetylchitohexaose and chitohexaose against Meth-A solid tumor. https://app.cochat.ai/papers/10.1248/cpb.36.784
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- TOKORO, A., TAKEWAKI, N., SUZUKI, K., MIKAMI, T., SUZUKI, S., & SUZUKI, M. (1988). Growth-inhibitory effect of hexa-N-acetylchitohexaose and chitohexaose against Meth-A solid tumor. Chemical and Pharmaceutical Bulletin. https://doi.org/10.1248/cpb.36.784
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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