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Biotransformation of (-)-Epicatechin 3-O-Gallate by Human Intestinal Bacteria.
Open accessAbstract
The biotransformation of (-)-epicatechin 3-O-gallate (1) and related compounds was undertaken using a human fecal suspension. Of fifteen metabolites isolated, four compounds were new, namely, two epimers of 1-(3'-hydroxyphenyl)-3-(2",4".6"-trihydroxyphenyl)propan-2-ols (6, 19); 2",3"-dihydroxyphenoxyl 3-(3',4'-dihydroxyphenyl)propionate (14) and 1-(3',4'-dihydroxyphenyl)-3-(2",4",6"-trihydroxyphenyl)propan-2-ol (18). (-)-Epicatechin (2), (-)-epigallocatechin (16) and their 3-O-gallates (1, 17) were extensively metabolized by a human fecal suspension after incubation for 24 h, whereas the gallates (1, 17) resisted any degradation by a rat fecal suspension, even after a prolonged incubation time (48 h), suggesting a difference in metabolic ability between two intestinal bacterial mixtures from different species.
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Cited by
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De Pascual-Teresa, S., Moreno, D. A., & García-Viguera, C. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11041679 · Cited by 559
Déprez, S., Mila, I., Lapierre, C., Brezillon, C., Rabot, S., Philippe, C., & Scalbert, A. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.11.2733 · Cited by 494
The chemistry and biotransformation of tea constituents
Sang, S., Lambert, J. D., Ho, C.-T., & Yang, C. S. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.02.007 · Cited by 492
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Metadata
- Authors
- MESELHY, M. R., NAKAMURA, N., & HATTORI, M.
- Venue
- Chemical and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 1997
- Volume
- 45
- Issue
- 5
- Pages
- 888-893
- ISSN
- 0009-2363 (ISSN-L)
- 1347-5223
- OpenAlex
- W1994438030
- Cited by
- 181
- References
- 0
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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- MESELHY, M. R., NAKAMURA, N., & HATTORI, M. (1997). Biotransformation of (-)-Epicatechin 3-O-Gallate by Human Intestinal Bacteria. Chemical and Pharmaceutical Bulletin. https://doi.org/10.1248/cpb.45.888
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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