The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Recent Developments in the Maytansinoid Antitumor Agents
Open accessAbstract
Maytansine and its congeners have been isolated from higher plants, mosses and from an Actinomycete, Actinosynnema pretiosum. Many of these compounds are antitumor agents of extraordinary potency, yet phase II clinical trials with maytansine proved disappointing. The chemistry and biology of maytansinoids has been reviewed repeatedly in the late 1970s and early 1980s; the present review covers new developments in this field during the last two decades. These include the use of maytansinoids as "warheads" in tumor-specific antibodies, preliminary metabolism studies, investigations of their biosynthesis at the biochemical and genetic level, and ecological issues related to the occurrence of such typical microbial metabolites in higher plants.
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Chari, R. V. J., Miller, M. L., & Widdison, W. C. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201307628 · Cited by 930
Chemical Ecology of Endophytic Fungi: Origins of Secondary Metabolites
Kusari, S., Hertweck, C., & Spiteller, M. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.06.004 · Cited by 743
Solvent-Free Heterocyclic Synthesis
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Metadata
- Authors
- Cassady, J. M., Chan, K. K., Floss, H. G., & Leistner, E.
- Venue
- CHEMICAL & PHARMACEUTICAL BULLETIN
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2004
- Volume
- 52
- Issue
- 1
- Pages
- 1-26
- ISSN
- 0009-2363 (ISSN-L)
- 1347-5223
- OpenAlex
- W2103498669
- Cited by
- 342
- References
- 56
- FWCI
- 7.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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